ArticleArthritis and rheumatism2011
Asymmetric loading and bone mineral density at the asymptomatic knees of patients with unilateral hip osteoarthritis.
Article in Arthritis and rheumatism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- A non-invasive, home-based biomechanical therapy for patients with spontaneous osteonecrosis of the knee.Journal of orthopaedic surgery and research · 2016Trial
- Asymmetrical biomechanics in knee osteoarthritis: a review of contralateral risk from primary disease to post-arthroplasty progression.EFORT open reviews · 2026Review
- Unilateral Single Joint Arthritis Changes Joint Power in Unaffected Joints.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Altered cumulative joint moments and increased joint moment symmetry during sit-to-stand transitions for transfemoral bone-anchored limb users: A case series.Clinical biomechanics (Bristol, Avon) · 2025Article
- Study on Bone Mineral Density Around the Knee in Postmenopausal Women with Osteoarthritis and Osteoporosis.International journal of women's health · 2025Article
- Comparison of quadriceps femoris properties, surface electromyography parameters and foot posture asymmetries between patients with unilateral and bilateral knee osteoarthritis.Frontiers in physiology · 2025Article
- A framework based on subject-specific musculoskeletal models and Monte Carlo simulations to personalize muscle coordination retraining.Scientific reports · 2024Article
- Stepping beyond Counts in Recovery of Total Knee Arthroplasty: A Prospective Study on Passively Collected Gait Metrics.Sensors (Basel, Switzerland) · 2023Article
- Body mass affects kinetic symmetry and inflammatory markers in adolescent knees during gait.Clinical biomechanics (Bristol, Avon) · 2023Article
- Lower limb joint loading in patients with unilateral hip osteoarthritis during bipedal stance and the effect of total hip replacement.Frontiers in bioengineering and biotechnology · 2023Article
- Asymmetries and relationships between muscle strength, proprioception, biomechanics, and postural stability in patients with unilateral knee osteoarthritis.Frontiers in bioengineering and biotechnology · 2022Article
- Comparison of Gait Symmetry and Joint Moments in Unilateral and Bilateral Hip Osteoarthritis Patients and Healthy Controls.Frontiers in bioengineering and biotechnology · 2021Article
- Instability and excessive mechanical loading mediate subchondral bone changes to induce osteoarthritis.Annals of translational medicine · 2020Article
- Quantifying Asymmetry in Gait: The Weighted Universal Symmetry Index to Evaluate 3D Ground Reaction Forces.Frontiers in bioengineering and biotechnology · 2020Article
- Gait Analysis Reveals that Total Hip Arthroplasty Increases Power Production in the Hip During Level Walking and Stair Climbing.Clinical orthopaedics and related research · 2019Article
- Gait asymmetries in unilateral symptomatic hip osteoarthritis and their association with radiographic severity and pain.Hip international : the journal of clinical and experimental research on hip pathology and therapy · 2019Article
- Programmed Sports Therapy (PST) in People with Haemophilia (PwH) "Sports Therapy Model for Rare Diseases".Orphanet journal of rare diseases · 2018Review
- Increased Hip Stresses Resulting From a Cam Deformity and Decreased Femoral Neck-Shaft Angle During Level Walking.Clinical orthopaedics and related research · 2017Article
- Patients with chronic non-specific low back pain who reported reduction in pain and improvement in function also demonstrated an improvement in gait pattern.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2016Article
- Do persons with asymmetric hip pain or radiographic hip OA have worse pain and structure outcomes in the knee opposite the more affected hip? Data from the Osteoarthritis Initiative.Osteoarthritis and cartilage · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveIn patients with unilateral end-stage hip osteoarthritis (OA), the contralateral knee is known to be at greater risk for end-stage knee OA compared to the ipsilateral (i.e., same-side) knee. The contralateral knee is known to have increased dynamic joint loads compared to the ipsilateral knee. The present study was undertaken to examine patients who had unilateral hip OA but who did not have symptoms of knee OA, in order to detect early asymmetries in knee loading.
methodsData on 62 patients with unilateral hip OA were evaluated. Patients underwent gait analyses of dynamic knee loads as well as dual x-ray absorptiometry for determination of bone mineral density (BMD) in both knees. Differences between knees were compared.
resultsPeak dynamic knee loads were significantly higher at the contralateral knee compared to the ipsilateral knee (mean ± SD 2.46 ± 0.71 percent of body weight × height versus 2.23 ± 0.81 percent of body weight × height; P = 0.029). Similarly, medial compartment tibial BMD was significantly higher in the contralateral knee compared to the ipsilateral knee (mean ± SD 0.897 ± 0.208 gm/cm(2) versus 0.854 ± 0.206 gm/cm(2); P = 0.033). Interestingly, there was a direct correlation between the contralateral:ipsilateral dynamic knee load and contralateral:ipsilateral medial compartment tibial BMD (ρ = 0.287, P = 0.036).
conclusionThe risk of developing progressive symptomatic OA in contralateral knees is higher compared to the risk in ipsilateral knees in patients with unilateral hip OA. The present study demonstrates that loading and structural asymmetries appear early in the disease course, while the knees are still asymptomatic. These early biomechanical asymmetries may have corresponding long-term consequences, providing further evidence for the potential role of loading in OA onset and progression.
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