ReviewSurgery today2012
Review: Single nucleotide polymorphisms associated with the oncogenesis of colorectal cancer.
Review in Surgery today, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese.International journal of medical sciences · 2020Article
- Association of rs6983267 at 8q24, HULC rs7763881 polymorphisms and serum lncRNAs CCAT2 and HULC with colorectal cancer in Egyptian patients.Scientific reports · 2017Article
- Functional STR withinInternational journal of clinical and experimental pathology · 2017Article
- Single Nucleotide Polymorphisms as Prognostic and Predictive Factors of Adjuvant Chemotherapy in Colorectal Cancer of Stages I and II.Gastroenterology research and practice · 2016Review
- Gender-specific association of NFKBIA promoter polymorphisms with the risk of sporadic colorectal cancer.Medical oncology (Northwood, London, England) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is provoked by interactions between genetic and environmental factors. We herein review the incidence and the mechanisms of action of the reported single nucleotide polymorphisms (SNPs) in the oncogenesis of CRC. More than 15 reports have studied the SNPs at 8q24, which are associated with the incidence of CRC as well as prostate cancer. We have also reported a SNP at the 10p14 locus, and the risks of other loci for CRC oncogenesis. With regard to the underlying mechanism for CRC, 8q24 is a locus of the long-enhancer site for MYC, which could determine the efficacy of MYC transcription. We suggest that 8q24 SNPs might be associated with the progression of CRC cases mediated by MYC expression. In this report, we summarize the published studies of the genetic background SNPs in the oncogenesis of CRC. The level of risk (most studies indicated less than a twofold increase) for CRC was lower than anticipated. Therefore, it is necessary to identify bona fide SNPs that precisely predict the risk for CRC. Alternatively, it is important to consider other factors, such as environmental or lifestyle-related factors, for the future prevention of CRC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.