Evidence map›Paper›PMID 22127477›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2012

Sudomotor dysfunction in autoimmune autonomic ganglionopathy: a follow-up study.

Kurt Kimpinski, Valeria Iodice, Paola Sandroni, Robert D Fealey, Steven Vernino, Phillip A Low

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kurt KimpinskiDepartment of Clinical Neurological Sciences, University Hospital, London Health Sciences Centre, University of Western Ontario, London, ON, Canada.
Valeria Iodice
Paola Sandroni
Robert D Fealey
Steven Vernino
Phillip A Low

Funding

MAYO CLINIC CENTER FOR TRANSLATIONAL SCIENCE ACTIVITIESUL1RR024150 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$66.4M
Studies on Diagnosis, Pathophysiology, and Treatment of Autonomic Failure in MSAP01NS044233 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOW, PHILLIP A · 2003 to 2014
$12.4M
SYMPATHETIC REGULATION OF VENOUS FUNCTION IN ORTHOSTATIC INTOLERANCE AND AGINGP50NS032352 · NINDS · MAYO CLINIC ROCHESTER · PI LOW, PHILLIP A · 1996 to 2009
$11.4M
Autonomic function/insulin resistance/multiethnic populS11NS043364 · NINDS · UNIVERSITY OF HAWAII AT MANOA · PI GRANDINETTI, ANDREW · 2003 to 2007
$1.5M
Peripheral Nerve IschemiaR01NS022352 · NINDS · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI LOW, PHILLIP A · 1985 to 2004
$1.1M
ELECTRODE ARRAYS BASED ON THIN FILM TECHNOLOGYN01NS032352 · NINDS · STANFORD UNIVERSITY · PI WHITE, ROBERT L · 1985 to 1985
–
ORTHOSTATIC INTOLERANCE IN AUTONOMIC NEUROPATHIES &POSTURAL TACHYCARDIA SYNDROMEP01NS032352 · NINDS · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI BENARROCH, EDUARDO E · 1995 to 1995
–
NCRR NIH HHS UL1 RR024150NCRR NIH HHS UL1 RR24150NINDS NIH HHS N01 NS032352NINDS NIH HHS NS065738NINDS NIH HHS NS 22352NINDS NIH HHS NS 32352NINDS NIH HHS NS 43364NINDS NIH HHS NS 44233NINDS NIH HHS P01 NS044233NINDS NIH HHS P50 NS032352NINDS NIH HHS R01 NS022352NINDS NIH HHS S11 NS043364
6 · The paper itself

Abstract

objectiveWe have previously shown that sudomotor dysfunction in autoimmune autonomic ganglionopathy is severe, widespread, and predominantly post-ganglionic. However, the long-term changes in sudomotor function have not been studied in detail. Our objective was to characterize the long-term changes in sudomotor dysfunction in patients with autoimmune autonomic ganglionopathy.

methodsChanges in sudomotor function were compared in a cohort of nine α3 nAChR antibody positive autoimmune autonomic ganglionopathy patients over an approximate 5-year period. Standard measurements of sudomotor function were used including the thermoregulatory sweat test and quantitative sudomotor axon reflex test.

resultsTotal body anhidrosis on thermoregulatory sweat testing showed improvement in four of nine patients. Quantitative sudomotor axon reflex testing for both forearm and foot sites was variable with four of nine patients showing improvement in total sweat output. Distribution of sudomotor dysfunction at follow-up was post-ganglionic in seven of nine patients at the foot site and three of nine patients at the forearm site. Overall, sudomotor dysfunction was post-ganglionic in seven of nine patients throughout the follow-up period (62.4 ± 19.4 months).

interpretationSudomotor dysfunction in autoimmune autonomic ganglionopathy was severe and widespread throughout the follow-up period for the majority of patients studied. Sudomotor dysfunction was predominantly post-ganglionic throughout the follow-up period.

Indexed as

AgedAutoimmune Diseases of the Nervous SystemAutonomic Nervous System DiseasesCohort StudiesComorbidityFemaleFollow-Up StudiesHumansMaleMiddle AgedSweat Gland Diseases

Identifiers

PMID22127477
PMCPMC3469317

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.