ArticleJournal of cancer research and clinical oncology2012
The role of leptin receptor gene polymorphisms in determining the susceptibility and prognosis of NSCLC in Chinese patients.
Article in Journal of cancer research and clinical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Associations between adipokines gene polymorphisms and knee osteoarthritis: a meta-analysis.BMC musculoskeletal disorders · 2022Pooled it
- Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: evidence from a meta-analysis.PloS one · 2013Pooled it
- Leptin receptor gene (A/G) polymorphism rs1137101 and renal cell carcinoma.Molecular and cellular biochemistry · 2018Trial
- A Model of Combination Therapy of Lewis Lung Carcinoma using Resection and Cytostatics.Bulletin of experimental biology and medicine · 2025Article
- Association of leptin receptor polymorphisms with susceptibility of non-small cell lung cancer: Evidence from 2249 subjects.Cancer medicine · 2024Review
- Autocrined leptin promotes proliferation of non-small cell lung cancer (NSCLC) viaAnnals of translational medicine · 2021Article
- The Effect of Leptin Receptor Gene Polymorphisms (R223Q and P1019P) in Susceptibility to Polycystic Ovarian Syndrome in Kurdish Women.International journal of fertility & sterility · 2021Article
- The Relationship Between rs3212986C>A Polymorphism and Tumor Stage in Lung Cancer Patients.Cureus · 2019Article
- Leptin induces epithelial-to-mesenchymal transition via activation of the ERK signaling pathway in lung cancer cells.Oncology letters · 2018Article
- Association of rs1137101 polymorphism in LEPR and susceptibility to knee osteoarthritis in a Northwest Chinese Han population.BMC musculoskeletal disorders · 2016Article
- Polymorphism in LEP and LEPR May Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer.International journal of endocrinology · 2015Article
- Lack of association betweenBiomedical reports · 2014Article
- Effects of leptin and leptin receptor gene polymorphisms on lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- [Advances of the relationship between leptin system and non-small cell lung cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2014Review
- Leptin receptor polymorphism Gln223Arg (rs1137101) in oral squamous cell carcinoma and potentially malignant oral lesions.SpringerPlus · 2014Article
- The leptin gene family and colorectal cancer: interaction with smoking behavior and family history of cancer.PloS one · 2013Article
- Role of leptin receptor (LEPR) gene polymorphisms and haplotypes in susceptibility to hepatocellular carcinoma in subjects with chronic hepatitis B virus infection.Molecular diagnosis & therapy · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimAlthough the role of genetic polymorphisms of leptin receptor (LEPR) gene in several cancers has been documented, the association between polymorphisms of LEPR gene and lung cancer remains unknown.
methodWe recruited 744 patients histologically diagnosed as non-small cell lung cancer (NSCLC) and 832 controls in this study. Polymorphism analysis of LEPR gene was performed by PCR-restriction fragment length polymorphisms.
resultsThe Arg/Arg genotype and Arg allele frequency of the Gln223Arg in LEPR gene were significantly prevalent in NSCLC subjects than in controls (P < 0.05). The odd ratio (OR) for NSCLC in Arg/Arg genotype carriers was 3.12 (95% CI: 2.25-4.56, P = 0.0023, with Gln/Gln as reference). There were no significant differences in the genotype distributions and allele frequencies of Lys109Arg and Lys656Asn in LEPR gene between NSCLC cases and controls (All P > 0.05). The Arg/Arg carriers had higher cancer grade and higher TNM stage. Kaplan-Mier curve showed the Arg/Arg carriers had a poor prognosis than those with Gln/Arg and Gln/Gln genotype carriers. Cox proportional hazards regression models showed the hazard ratio (HR) for death associated with Arg/Arg genotype was 3.43 (95% CI: 2.45-5.92, compared with Gln/Gln carriers, P = 0.002). The other two SNPs of LEPR gene did not show this trend in the evaluation of their role in determining the prognosis of NSCLC subjects.
conclusionThe results suggest the polymorphisms of Gln223Arg, rather than Lys109Arg and Lys656Asn, may be used as a molecular marker for progression and prognosis of NSCLC.
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