Evidence map›Paper›PMID 22126913›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2012

Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism.

Yilong Ma, Shichun Peng, Phoebe G Spetsieris, Vesna Sossi, David Eidelberg, Doris J Doudet

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Network Structure and Function in Parkinson's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2018
    Article
  6. Review
  7. The use of nonhuman primate models to understand processes in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2018
    Review
  8. Article
  9. Article
  10. Article
  11. Reverse Translation in Parkinson Disease.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2016
    Article
  12. Neuroimaging of Parkinson's disease: Expanding views.Neuroscience and biobehavioral reviews · 2015
    Review
  13. Article
  14. Review
  15. Effects of levodopa on regional cerebral metabolism and blood flow.Movement disorders : official journal of the Movement Disorder Society · 2015
    Review
  16. Review
  17. Article
  18. Parkinson's disease: increased motor network activity in the absence of movement.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yilong MaCenter for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA. yma@nshs.edu
Shichun Peng
Phoebe G Spetsieris
Vesna Sossi
David Eidelberg
Doris J Doudet
Center for Neurosciences · USUniversity of British Columbia · CAFeinstein Institute for Medical Research · US

Funding

Statistics and Data Management CoreP50NS071675 · NINDS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI FEIGIN, ANDREW · 2010 to 2014
$9.3M
CIHR CTP-79851NINDS NIH HHS P50 NS071675
6 · The paper itself

Abstract

Parkinson's disease (PD) is associated with a characteristic regional metabolic covariance pattern that is modulated by treatment. To determine whether a homologous metabolic pattern is also present in nonhuman primate models of parkinsonism, 11 adult macaque monkeys with parkinsonism secondary to chronic systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 12 age-matched healthy animals were scanned with [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET). A subgroup comprising five parkinsonian and six control animals was used to identify a parkinsonism-related pattern (PRP). For validation, analogous topographies were derived from other subsets of parkinsonian and control animals. The PRP topography was characterized by metabolic increases in putamen/pallidum, thalamus, pons, and sensorimotor cortex, as well as reductions in the posterior parietal-occipital region. Pattern expression was significantly elevated in parkinsonian relative to healthy animals (P<0.00001). Parkinsonism-related topographies identified in the other derivation sets were very similar, with significant pairwise correlations of region weights (r>0.88; P<0.0001) and subject scores (r>0.74; P<0.01). Moreover, pattern expression in parkinsonian animals correlated with motor ratings (r>0.71; P<0.05). Thus, homologous parkinsonism-related metabolic networks are demonstrable in PD patients and in monkeys with experimental parkinsonism. Network quantification may provide a useful biomarker for the evaluation of new therapeutic agents in preclinical models of PD.

Indexed as

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsDisease Models, AnimalDopamine AgentsFemaleHumansMacacaMaleParkinsonian DisordersPutamenThalamus1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineDopamine Agents

Identifiers

PMID22126913
PMCPMC3318142
OpenAlexW2082838000

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.