ReviewBioengineered bugs2012
Evolutionary, ecological and biotechnological perspectives on plasmids resident in the human gut mobile metagenome.
Review in Bioengineered bugs, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- A plasmid network from the gut microbiome of semi-isolated human groups reveals unique and shared metabolic and virulence traits.Scientific reports · 2022Article
- Metagenomic assembled plasmids of the human microbiome vary across disease cohorts.Scientific reports · 2022Article
- A Peek into the Plasmidome of Global Sewage.mSystems · 2021Article
- Contagious Antibiotic Resistance: Plasmid Transfer among Bacterial Residents of the Zebrafish Gut.Applied and environmental microbiology · 2021Article
- Conjugation dynamics depend on both the plasmid acquisition cost and the fitness cost.Molecular systems biology · 2021Article
- Modulating the gut-liver axis and the pivotal role of the faecal microbiome in cirrhosis.Clinical medicine (London, England) · 2020Review
- Antimicrobial resistance in chronic liver disease.Hepatology international · 2020Review
- Long-read metagenomic exploration of extrachromosomal mobile genetic elements in the human gut.Microbiome · 2019Article
- Tracking the Rules of Transmission and Introgression with Networks.Microbiology spectrum · 2018Review
- Association of the gut microbiota mobilome with hospital location and birth weight in preterm infants.Pediatric research · 2017Article
- Escherichia coli Nissle 1917 enhances bioavailability of serotonin in gut tissues through modulation of synthesis and clearance.Scientific reports · 2015Article
- Rethinking evolutionary individuality.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The human gut resistome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- The human gut virome: a multifaceted majority.Frontiers in microbiology · 2015Review
- Comparative (meta)genomic analysis and ecological profiling of human gut-specific bacteriophage φB124-14.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Numerous mobile genetic elements (MGE) are associated with the human gut microbiota and collectively referred to as the gut mobile metagenome. The role of this flexible gene pool in development and functioning of the gut microbial community remains largely unexplored, yet recent evidence suggests that at least some MGE comprising this fraction of the gut microbiome reflect the co-evolution of host and microbe in the gastro-intestinal tract. In conjunction, the high level of novel gene content typical of MGE coupled with their predicted high diversity, suggests that the mobile metagenome constitutes an immense and largely unexplored gene-space likely to encode many novel activities with potential biotechnological or pharmaceutical value, as well as being important to the development and functioning of the gut microbiota. Of the various types of MGE that comprise the gut mobile metagenome, plasmids are of particular importance since these elements are often capable of autonomous transfer between disparate bacterial species, and are known to encode accessory functions that increase bacterial fitness in a given environment facilitating bacterial adaptation. In this article current knowledge regarding plasmids resident in the human gut mobile metagenome is reviewed, and available strategies to access and characterize this portion of the gut microbiome are described. The relative merits of these methods and their present as well as prospective impact on our understanding of the human gut microbiota is discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.