ArticleCritical care (London, England)2011
Pandemic and post-pandemic influenza A (H1N1) infection in critically ill patients.
Article in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Is Extracorporeal Membrane Oxygenation the Standard Care for Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis.Heart, lung & circulation · 2021Pooled it
- Pregnancy as a risk factor for severe influenza infection: an individual participant data meta-analysis.BMC infectious diseases · 2019Pooled it
- Pooled it
- Challenges and opportunities in the management of severe pneumonia. Key concepts from the Seventh Annual Meeting of Spanish Experts 2025.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Review
- Outcomes among critically ill adults with influenza infection.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2021Article
- Effects of human immunodeficiency virus status on symptom severity in influenza-like illness in an otherwise healthy adult outpatient cohort.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2021Observational
- Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia.ERJ open research · 2021Article
- Determinants of Fatal Outcome in Patients Admitted to Intensive Care Units With Influenza, European Union 2009-2017.Open forum infectious diseases · 2019Article
- Influenza and associated co-infections in critically ill immunosuppressed patients.Critical care (London, England) · 2019Article
- Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study.Intensive care medicine · 2018Observational
- Severe morbidity among hospitalised adults with acute influenza and other respiratory infections: 2014-2015 and 2015-2016.Epidemiology and infection · 2018Article
- ICU-treated influenza A(H1N1) pdm09 infections more severe post pandemic than during 2009 pandemic: a retrospective analysis.BMC infectious diseases · 2017Article
- Increased incidence of co-infection in critically ill patients with influenza.Intensive care medicine · 2017Article
- Extra-corporeal membrane oxygenation as an indispensable tool for a successful treatment of a pregnant woman with H1N1 infection in Brazil.Respiratory medicine case reports · 2017Article
- Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome.Critical care (London, England) · 2016Article
- Neces-SARI-ly?Intensive care medicine · 2016Article
- The Intensive Care Global Study on Severe Acute Respiratory Infection (IC-GLOSSARI): a multicenter, multinational, 14-day inception cohort study.Intensive care medicine · 2016Article
- Critical illness associated with 2013-2014 influenza A (H1N1): Postpandemic characteristics, presentation and outcomes.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2015Article
- Critically ill patients with H7N9: new virus, old challenges*.Critical care medicine · 2015Article
- Postpandemic Influenza A/H1N1pdm09 is still Causing Severe Perinatal Complications.Mediterranean journal of hematology and infectious diseases · 2015Article
Corrections and comments
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Authors and funding
16 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a vast amount of information published regarding the impact of 2009 pandemic Influenza A (pH1N1) virus infection. However, a comparison of risk factors and outcome during the 2010-2011 post-pandemic period has not been described.
methodsA prospective, observational, multi-center study was carried out to evaluate the clinical characteristics and demographics of patients with positive RT-PCR for H1N1 admitted to 148 Spanish intensive care units (ICUs). Data were obtained from the 2009 pandemic and compared to the 2010-2011 post-pandemic period.
resultsNine hundred and ninety-seven patients with confirmed An/H1N1 infection were included. Six hundred and forty-eight patients affected by 2009 (pH1N1) virus infection and 349 patients affected by the post-pandemic Influenza (H1N1)v infection period were analyzed. Patients during the post-pandemic period were older, had more chronic comorbid conditions and presented with higher severity scores (Acute Physiology And Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA)) on ICU admission. Patients from the post-pandemic Influenza (H1N1)v infection period received empiric antiviral treatment less frequently and with delayed administration. Mortality was significantly higher in the post-pandemic period. Multivariate analysis confirmed that haematological disease, invasive mechanical ventilation and continuous renal replacement therapy were factors independently associated with worse outcome in the two periods. HIV was the only new variable independently associated with higher ICU mortality during the post-pandemic Influenza (H1N1)v infection period.
conclusionPatients from the post-pandemic Influenza (H1N1)v infection period had an unexpectedly higher mortality rate and showed a trend towards affecting a more vulnerable population, in keeping with more typical seasonal viral infection.
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