ArticleBMC medical genetics2011
Heritability of physical activity traits in Brazilian families: the Baependi Heart Study.
Article in BMC medical genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- An Extended Twin-Pedigree Study of Different Classes of Voluntary Exercise Behavior.Behavior genetics · 2020Article
- Heritability and Sex-Specific Genetic Effects of Self-Reported Physical Activity in a Brazilian Highly Admixed Population.Human heredity · 2019Article
- Biological/Genetic Regulation of Physical Activity Level: Consensus from GenBioPAC.Medicine and science in sports and exercise · 2018Review
- Timing and quality of sleep in a rural Brazilian family-based cohort, the Baependi Heart Study.Scientific reports · 2016Article
- Cohort profile: the Baependi Heart Study-a family-based, highly admixed cohort study in a rural Brazilian town.BMJ open · 2016Article
- Sex-specific genetic effects in physical activity: results from a quantitative genetic analysis.BMC medical genetics · 2015Article
- Genotype by sex and genotype by age interactions with sedentary behavior: the Portuguese Healthy Family Study.PloS one · 2014Article
- DRD4 genotype predicts longevity in mouse and human.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Genetic and environmental influences on blood pressure and physical activity: a study of nuclear families from Muzambinho, Brazil.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2012Article
- Familial aggregation and heritability of markers of metabolic risk, physical activity, and physical fitness in nuclear families from Muzambinho (Minas Gerais, Brazil).Archives of endocrinology and metabolismArticle
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Authors and funding
8 authors.
Funding
Abstract
backgroundIt is commonly recognized that physical activity has familial aggregation; however, the genetic influences on physical activity phenotypes are not well characterized. This study aimed to (1) estimate the heritability of physical activity traits in Brazilian families; and (2) investigate whether genetic and environmental variance components contribute differently to the expression of these phenotypes in males and females.
methodsThe sample that constitutes the Baependi Heart Study is comprised of 1,693 individuals in 95 Brazilian families. The phenotypes were self-reported in a questionnaire based on the WHO-MONICA instrument. Variance component approaches, implemented in the SOLAR (Sequential Oligogenic Linkage Analysis Routines) computer package, were applied to estimate the heritability and to evaluate the heterogeneity of variance components by gender on the studied phenotypes.
resultsThe heritability estimates were intermediate (35%) for weekly physical activity among non-sedentary subjects (weekly PA_NS), and low (9-14%) for sedentarism, weekly physical activity (weekly PA), and level of daily physical activity (daily PA). Significant evidence for heterogeneity in variance components by gender was observed for the sedentarism and weekly PA phenotypes. No significant gender differences in genetic or environmental variance components were observed for the weekly PA_NS trait. The daily PA phenotype was predominantly influenced by environmental factors, with larger effects in males than in females.
conclusionsHeritability estimates for physical activity phenotypes in this sample of the Brazilian population were significant in both males and females, and varied from low to intermediate magnitude. Significant evidence for heterogeneity in variance components by gender was observed. These data add to the knowledge of the physical activity traits in the Brazilian study population, and are concordant with the notion of significant biological determination in active behavior.
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