ArticleReproductive biology and endocrinology : RB&E2011
Modulation of the endocannabinoid system in viable and non-viable first trimester pregnancies by pregnancy-related hormones.
Article in Reproductive biology and endocrinology : RB&E, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Endocannabinoid System Regulation in Pyometra-Affected and Healthy Canine Uteri.Veterinary sciences · 2025Article
- Endometrial Receptivity-Lessons from "Omics".Biomolecules · 2025Review
- Labour and premature delivery differentially affect the expression of the endocannabinoid system in the human placenta.Histochemistry and cell biology · 2023Article
- Construction of machine learning tools to predict threatened miscarriage in the first trimester based on AEA, progesterone and β-hCG in China: a multicentre, observational, case-control study.BMC pregnancy and childbirth · 2022Observational
- Development of Machine Learning Tools for Predicting Coronary Artery Disease in the Chinese Population.Disease markers · 2022Article
- Metabolic Consequences of Gestational Cannabinoid Exposure.International journal of molecular sciences · 2021Review
- Nitric oxide positively affects endometrial receptivity via FAAH and NAPE-PLDReproduction & fertility · 2021Article
- Review
- Evaluating the agreement of ultrasound imaging and beta-human chorionic gonadotropin (β-hCG) measurement in confirming completed medical abortion: cross-sectional study.Qatar medical journal · 2021Article
- (Endo)Cannabinoids and Gynaecological Cancers.Cancers · 2020Review
- The fundamental role of the endocannabinoid system in endometrium and placenta: implications in pathophysiological aspects of uterine and pregnancy disorders.Human reproduction update · 2020Review
- Article
- New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System.Medical science monitor basic research · 2019Article
- Expression and Function of the Endocannabinoid Modulating Enzymes Fatty Acid Amide Hydrolase andFrontiers in oncology · 2019Article
- Diagnostic value of detection of serum β-HCG and CT-IgG combined with transvaginal ultrasonography in early tubal pregnancy.Experimental and therapeutic medicine · 2018Article
- Marijuana use differentially affects cannabinoid receptor expression in early gestational human endometrium and placenta.Placenta · 2018Article
- Crosstalk Between Nitric Oxide and Endocannabinoid Signaling Pathways in Normal and Pathological Placentation.Frontiers in physiology · 2018Review
- Marijuana, the Endocannabinoid System and the Female Reproductive System.The Yale journal of biology and medicine · 2016Review
- Lipopolysaccharide-induced murine embryonic resorption involves changes in endocannabinoid profiling and alters progesterone secretion and inflammatory response by a CB1-mediated fashion.Molecular and cellular endocrinology · 2015Article
- A role for GPR55 in human placental venous endothelial cells.Histochemistry and cell biology · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn early pregnancy, increased plasma levels of the endocannabinoid anandamide (AEA) are associated with miscarriage through mechanisms that might affect the developing placenta or maternal decidua.
methodsIn this study, we compare AEA levels in failed and viable pregnancies with the levels of the trophoblastic hormones (beta-human chorionic gonadotrophin (beta-hCG), progesterone (P4) and (pregnancy-associated placental protein-A (PAPP-A)) essential for early pregnancy success and relate that to the expression of the cannabinoid receptors and enzymes that modulate AEA levels.
resultsThe median plasma AEA level in non-viable pregnancies (1.48 nM; n = 20) was higher than in viable pregnancies (1.21 nM; n = 25; P = 0.013), as were progesterone and beta-hCG levels (41.0 vs 51.5 ng/mL; P = 0.052 for P4 and 28,650 vs 6,560 mIU/L; P = 0.144 for beta-hCG, respectively, but were not statistically significant). Serum PAPP-A levels in the viable group were approximately 6.8 times lower than those in the non-viable group (1.82 vs 12.25 mg/L; P = 0.071), but again these differences were statistically insignificant. In the spontaneous miscarriage group, significant correlations between P4 and beta-hCG, P4 and PAPP-A and AEA and PAPP-A levels were observed. Simultaneously, immunohistochemical distributions of the two main cannabinoid receptors and the AEA-modifying enzymes, fatty acid amide hydrolase (FAAH) and N-acylphosphatidylethanolamine-phospholipase D (NAPE-PLD), changed within both the decidua and trophoblast.
conclusionsThe association of higher AEA levels with early pregnancy failure and with beta-hCG and PAPP-A, but not with progesterone concentrations suggest that plasma AEA levels and pregnancy failure are linked via a mechanism that may involve trophoblastic beta-hCG, and PAPP-A, but not, progesterone production. Although the trophoblast, decidua and embryo contain receptors for AEA, the main AEA target in early pregnancy failure remains unknown.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.