ReviewACS chemical biology2012
Chemistry and biology of the copper chelator methanobactin.
Review in ACS chemical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 85 citations in OpenAlex.
- Discovery of Isonitrile Lipopeptide Chalkophores from Pathogenic Mycobacteria.Journal of natural products · 2025Article
- Cuproptosis in prostate cancer: Molecular mechanisms, prognostic biomarkers and therapeutic frontiers of cuproptosis‑related genes (Review).International journal of oncology · 2025Review
- A multi-iron enzyme installs copper-binding oxazolone/thioamide pairs on a nontypeableProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications.Current opinion in chemical biology · 2024Review
- LCMS-Metabolomic Profiling and Genome Mining ofJournal of natural products · 2024Article
- Structures of the holoenzyme TglHI required for 3-thiaglutamate biosynthesis.Structure (London, England : 1993) · 2023Article
- Cuproptosis: mechanisms and links with cancers.Molecular cancer · 2023Review
- Screening for Microbial Metal-Chelating Siderophores for the Removal of Metal Ions from Solutions.Microorganisms · 2021Article
- Hybridization of Particulate Methane Monooxygenase by Methanobactin-Modified AuNPs.Molecules (Basel, Switzerland) · 2019Article
- Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products.Science (New York, N.Y.) · 2019Article
- Biosynthesis and Chemical Applications of Thioamides.ACS chemical biology · 2019Review
- Cu-induced assembly of methanobactin-modified gold nanoparticles and its peroxidase mimic activity.IET nanobiotechnology · 2018Article
- Chalkophores.Annual review of biochemistry · 2018Review
- Enzymatic reconstitution of ribosomal peptide backbone thioamidation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Methanobactins: from genome to function.Metallomics : integrated biometal science · 2017Review
- Bacterial cytosolic proteins with a high capacity for Cu(I) that protect against copper toxicity.Scientific reports · 2016Article
- Methanobactin transport machinery.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Characterization of Methanobactin from Methylosinus sp. LW4.Journal of the American Chemical Society · 2016Article
- Methane-Oxidizing Enzymes: An Upstream Problem in Biological Gas-to-Liquids Conversion.Journal of the American Chemical Society · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Methanotrophic bacteria, organisms that oxidize methane, produce a small copper chelating molecule called methanobactin (Mb). Mb binds Cu(I) with high affinity and is hypothesized to mediate copper acquisition from the environment. Recent advances in Mb characterization include revision of the chemical structure of Mb from Methylosinus trichosporium OB3b and further investigation of its biophysical properties. In addition, Mb production by several other methanotroph strains has been investigated, and preliminary characterization suggests diversity in chemical composition. Initial clues into Mb biosynthesis have been obtained by identification of a putative precursor gene in the M. trichosporium OB3b genome. Finally, direct uptake of intact Mb into the cytoplasm of M. trichosporium OB3b cells has been demonstrated, and studies of the transport mechanism have been initiated. Taken together, these advances represent significant progress and set the stage for exciting new research directions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.