ArticlePloS one2011
Emergence and transmission pathways of rapidly evolving evolutionary branch C4a strains of human enterovirus 71 in the Central Plain of China.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- The emerging sub-genotype C2 of CoxsackievirusA10 Associated with Hand, Foot and Mouth Disease extensively circulating in mainland of China.Scientific reports · 2018Trial
- Biological characteristics of an enterovirus A71 subgroup C4 strain isolated in China.BMC infectious diseases · 2025Article
- Molecular Evolutionary Dynamics of Coxsackievirus A6 Causing Hand, Foot, and Mouth Disease From 2021 to 2023 in China: Genomic Epidemiology Study.JMIR public health and surveillance · 2024Article
- Genetic diversity and recombination of bovine enterovirus strains in China.Microbiology spectrum · 2024Article
- Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study.Virology journal · 2022Article
- Whole-genome analysis of coxsackievirus B3 reflects its genetic diversity in China and worldwide.Virology journal · 2022Article
- Highly diverse ribonucleic acid viruses in the viromes of eukaryotic host species in Yunnan province, China.Frontiers in microbiology · 2022Article
- Global emergence of Enterovirus 71: a systematic review.Beni-Suef University journal of basic and applied sciences · 2022Review
- Epidemiology and Sequence-Based Evolutionary Analysis of Circulating Non-Polio Enteroviruses.Microorganisms · 2020Review
- Genomic epidemiology of coxsackievirus A16 in mainland of China, 2000-18.Virus evolution · 2020Article
- Global Spread of the B5 Subgenotype EV-A71 and the Phylogeographical Analysis of Chinese Migration Events.Frontiers in cellular and infection microbiology · 2020Article
- Molecular typing and characterization of a novel genotype of EV-B93 isolated from Tibet, China.PloS one · 2020Article
- Molecular Epidemiology of Echovirus 18 Circulating in Mainland China from 2015 to 2016.Virologica Sinica · 2019Article
- Enterovirus-Human Rhinovirus as a Leading Cause of ARDS in a Liver Transplant Recipient.Tanaffos · 2019Article
- Severity of enterovirus A71 infection in a human SCARB2 knock-in mouse model is dependent on infectious strain and route.Emerging microbes & infections · 2018Article
- Hand, foot and mouth disease and herpangina caused by enterovirus A71 infections: a review of enterovirus A71 molecular epidemiology, pathogenesis, and current vaccine development.Revista do Instituto de Medicina Tropical de Sao Paulo · 2018Review
- Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008-2015.Emerging infectious diseases · 2018Article
- Persistent circulation of genotype D coxsackievirus A2 in mainland of China since 2008.PloS one · 2018Article
- Persistent circulation of Coxsackievirus A6 of genotype D3 in mainland of China between 2008 and 2015.Scientific reports · 2017Article
- Phylogenetic Characterizations of Highly Mutated EV-B106 Recombinants Showing Extensive Genetic Exchanges with Other EV-B in Xinjiang, China.Scientific reports · 2017Article
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Authors and funding
16 authors.
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Abstract
backgroundLarge-scale outbreaks of hand, foot, and mouth disease (HFMD) occurred repeatedly in the Central Plain of China (Shandong, Anhui, and Henan provinces) from 2007 until now. These epidemics have increased in size and severity each year and are a major public health concern in mainland China. PRINCIPAL
findingsPhylogenetic analysis was performed and a Bayesian Markov chain Monte Carlo tree was constructed based on the complete VP1 sequences of HEV71 isolates. These analyses showed that the HFMD epidemic in the Central Plain of China was caused by at least 5 chains of HEV71 transmission and that the virus continued to circulate and evolve over the winter seasons between outbreaks. Between 1998 and 2010, there were 2 stages of HEV71 circulation in mainland China, with a shift from evolutionary branch C4b to C4a in 2003-2004. The evolution rate of C4a HEV71 was 4.99×10(-3) substitutions per site per year, faster than the mean of all HEV71 genotypes. The most recent common ancestor estimates for the Chinese clusters dated to October 1994 and November 1993 for the C4a and C4b evolutionary branches, respectively. Compared with all C4a HEV71 strains, a nucleotide substitution in all C4b HEV71 genome (A to C reversion at nt2503 in the VP1 coding region, which caused amino acid substitution of VP1-10: Gln to His) had reverted.
conclusionsThe data suggest that C4a HEV71 strains introduced into the Central Plain of China are responsible for the recent outbreaks. The relationships among HEV71 isolates determined from the combined sequence and epidemiological data reveal the underlying seasonal dynamics of HEV71 circulation. At least 5 HEV71 lineages circulated in the Central Plain of China from 2007 to 2009, and the Shandong and Anhui lineages were found to have passed through a genetic bottleneck during the low-transmission winter season.
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