ArticlePloS one2011
Default-mode-like network activation in awake rodents.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
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- Disrupted Topological Organization of Brain Network in Rats with Spatial Memory Impairments Induced by Acute Microwave Radiation.Brain sciences · 2023Article
- Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats.Frontiers in neuroscience · 2023Article
- Connecting the dots between cell populations, whole-brain activity, and behavior.Neurophotonics · 2022Article
- Remote contextual fear retrieval engages activity from salience network regions in rats.Neurobiology of stress · 2022Article
- Functional Connectivity of the Brain Across Rodents and Humans.Frontiers in neuroscience · 2022Review
- Applications in Awake Animal Magnetic Resonance Imaging.Frontiers in neuroscience · 2022Review
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- Retrosplenial Cortical Connectivity with Frontal Basal Ganglia Networks.Journal of cognitive neuroscience · 2021Article
- Regional, Layer, and Cell-Type-Specific Connectivity of the Mouse Default Mode Network.Neuron · 2021Article
- The neural basis of attentional alterations in prenatally protein malnourished rats.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Electrophysiological Correlates of Rodent Default-Mode Network Suppression Revealed by Large-Scale Local Field Potential Recordings.Cerebral cortex communications · 2021Article
- The functional networks of a novel environment: Neural activity mapping in awake unrestrained rats using positron emission tomography.Brain and behavior · 2020Article
- Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat.NeuroImage · 2020Article
- Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis.NeuroImage · 2020Article
- Delayed Functional Networks Development and Altered Fast Oscillation Dynamics in a Rat Model of Cortical Malformation.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During wakefulness and in absence of performing tasks or sensory processing, the default-mode network (DMN), an intrinsic central nervous system (CNS) network, is in an active state. Non-human primate and human CNS imaging studies have identified the DMN in these two species. Clinical imaging studies have shown that the pattern of activity within the DMN is often modulated in various disease states (e.g., Alzheimer's, schizophrenia or chronic pain). However, whether the DMN exists in awake rodents has not been characterized. The current data provides evidence that awake rodents also possess 'DMN-like' functional connectivity, but only subsequent to habituation to what is initially a novel magnetic resonance imaging (MRI) environment as well as physical restraint. Specifically, the habituation process spanned across four separate scanning sessions (Day 2, 4, 6 and 8). At Day 8, significant (p<0.05) functional connectivity was observed amongst structures such as the anterior cingulate (seed region), retrosplenial, parietal, and hippocampal cortices. Prior to habituation (Day 2), functional connectivity was only detected (p<0.05) amongst CNS structures known to mediate anxiety (i.e., anterior cingulate (seed region), posterior hypothalamic area, amygdala and parabracial nucleus). In relating functional connectivity between cingulate-default-mode and cingulate-anxiety structures across Days 2-8, a significant inverse relationship (r = -0.65, p = 0.0004) was observed between these two functional interactions such that increased cingulate-DMN connectivity corresponded to decreased cingulate anxiety network connectivity. This investigation demonstrates that the cingulate is an important component of both the rodent DMN-like and anxiety networks.
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