ArticleDrug discovery today. Disease models2011
Cardiovascular Regulation in Obstructive Sleep Apnea.
Article in Drug discovery today. Disease models, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Impact of beta-blockers on mortality and cardiovascular disease outcomes in patients with obstructive sleep apnoea: a population-based cohort study in target trial emulation framework.The Lancet regional health. Europe · 2023Article
- Management of hypertension in obstructive sleep apnea.American journal of preventive cardiology · 2023Review
- The association between sleep deprivation and arterial pressure variations: a systematic literature review.Sleep medicine: X · 2022Review
- Leptin: A Potential Link Between Obstructive Sleep Apnea and Obesity.Frontiers in physiology · 2021Article
- Associations between primary aldosteronism and diabetes, poor bone health, and sleep apnea-what do we know so far?Journal of human hypertension · 2020Review
- Apneic Sleep, Insufficient Sleep, and Hypertension.Hypertension (Dallas, Tex. : 1979) · 2019Review
- Ankylosing Spondylitis Is Associated With Risk of New-Onset Obstructive Sleep Apnea: A Nationwide Population-Based Cohort Study.Frontiers in medicine · 2019Article
- Review of and Updates on Hypertension in Obstructive Sleep Apnea.International journal of hypertension · 2017Review
- Healthcare Service Utilization by Patients with Obstructive Sleep Apnea: A Population-Based Study.PloS one · 2015Article
- Chemoreflexes, sleep apnea, and sympathetic dysregulation.Current hypertension reports · 2014Review
- The efficacy of antihypertensive drugs in chronic intermittent hypoxia conditions.Frontiers in physiology · 2014Review
- Quintessential risk factors: their role in promoting cognitive dysfunction and Alzheimer's disease.Neurochemical research · 2012Review
- Cerebrovascular consequences of obstructive sleep apnea.Journal of the American Heart Association · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The majority of patients with obstructive sleep apnea (OSA) suffer from hypertension as a complication of both the metabolic syndrome and OSA. In animal studies, intermittent hypoxia that simulates changes seen in OSA leads to chemoreceptor and chromaffin cell stimulation of sympathetic nerve activity, endothelial damage and impaired blood pressure modulation. Human studies reveal activation of sympathetic nerves, endothelial damage and exaggerated pressor responses to sympathetic neurotransmitters and endothelin. Although treatment of the OSA normalizes sympathetic nerve responses, it only lowers blood pressure modestly. Agents that block the consequences of sympathetic over activity, such as β1 blockers and angiotensin antagonists have effectively lowered blood pressure. Diuretics have been less successful. Treatment of hypertensive patients with OSA usually requires consideration of both increased sympathetic nerve activity and the metabolic syndrome.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.