ArticleDrug discovery today. Disease models2011
Angiogenesis and Proteinases: Influence on Vascular Morphogenesis, Stabilization and Regression.
Article in Drug discovery today. Disease models, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Therapeutic potential of inhibitors of gelatinases MMP-2 and MMP-9 for the treatment of breast cancer.The FEBS journal · 2026Review
- Alphastatin-C a new inhibitor of endothelial cell activation is a pro-arteriogenic agentOncotarget · 2020Article
- Identification of an Endogenously Generated Cryptic Collagen Epitope (XL313) That May Selectively Regulate Angiogenesis by an Integrin Yes-associated Protein (YAP) Mechano-transduction Pathway.The Journal of biological chemistry · 2016Article
- Article
- Pericyte dynamics during angiogenesis: new insights from new identities.Journal of vascular research · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Proteinases play a key role during angiogenesis and have been implicated in vascular morphogenesis, stabilization and regression. Major advances have identified specific proteinases and their inhibitors that separately control these processes. Relevant proteinases include cell surface or soluble metalloproteinases, serine proteinases and cathepsins that affect these events and a critical issue concerns how these proteinases are balanced by their inhibitors to affect tissue vascularization. Importantly, heterotypic communication of endothelial cells with vessel supporting cells such as pericytes controls proteinase and inhibitor expression to regulate these processes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.