ArticlePLoS genetics2011
Heritable epigenetic variation among maize inbreds.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
78 citing papers in PubMed, 165 citations in OpenAlex.
- DNA methylation variations underlie lettuce domestication and divergence.Genome biology · 2024Article
- Uncovering epigenetic and transcriptional regulation of growth in Douglas-fir: identification of differential methylation regions in mega-sized introns.Plant biotechnology journal · 2024Article
- Review
- Unveiling the Mysteries of Non-Mendelian Heredity in Plant Breeding.Plants (Basel, Switzerland) · 2023Review
- Epigenetic Changes Occurring in Plant Inbreeding.International journal of molecular sciences · 2023Review
- Physiological, Biochemical, and Epigenetic Reaction of Maize (International journal of molecular sciences · 2023Article
- Domestication Shapes Recombination Patterns in Tomato.Molecular biology and evolution · 2022Article
- MethylScore, a pipeline for accurate and context-aware identification of differentially methylated regions from population-scale plant whole-genome bisulfite sequencing data.Quantitative plant biology · 2022Article
- The Underlying Nature of Epigenetic Variation: Origin, Establishment, and Regulatory Function of Plant Epialleles.International journal of molecular sciences · 2021Review
- Stability of DNA methylation and chromatin accessibility in structurally diverse maize genomes.G3 (Bethesda, Md.) · 2021Article
- An epigenetic basis of inbreeding depression in maize.Science advances · 2021Article
- Maize DNA Methylation in Response to Drought Stress Is Involved in Target Gene Expression and Alternative Splicing.International journal of molecular sciences · 2021Article
- Heritable epigenetic diversity for conservation and utilization of epigenetic germplasm resources of clonal East African Highland banana (EAHB) accessions.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Epigenomic landscape and epigenetic regulation in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- Genome-wide expression quantitative trait locus analysis in a recombinant inbred line population for trait dissection in peanut.Plant biotechnology journal · 2020Article
- Establishment, maintenance, and biological roles of non-CG methylation in plants.Essays in biochemistry · 2019Review
- Identification of the expressome by machine learning on omics data.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Intragenic Meiotic Crossovers Generate Novel Alleles with Transgressive Expression Levels.Molecular biology and evolution · 2018Article
- Subtle Perturbations of the Maize Methylome Reveal Genes and Transposons Silenced by Chromomethylase or RNA-Directed DNA Methylation Pathways.G3 (Bethesda, Md.) · 2018Article
- Exploiting induced and natural epigenetic variation for crop improvement.Nature reviews. Genetics · 2017Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic variation describes heritable differences that are not attributable to changes in DNA sequence. There is the potential for pure epigenetic variation that occurs in the absence of any genetic change or for more complex situations that involve both genetic and epigenetic differences. Methylation of cytosine residues provides one mechanism for the inheritance of epigenetic information. A genome-wide profiling of DNA methylation in two different genotypes of Zea mays (ssp. mays), an organism with a complex genome of interspersed genes and repetitive elements, allowed the identification and characterization of examples of natural epigenetic variation. The distribution of DNA methylation was profiled using immunoprecipitation of methylated DNA followed by hybridization to a high-density tiling microarray. The comparison of the DNA methylation levels in the two genotypes, B73 and Mo17, allowed for the identification of approximately 700 differentially methylated regions (DMRs). Several of these DMRs occur in genomic regions that are apparently identical by descent in B73 and Mo17 suggesting that they may be examples of pure epigenetic variation. The methylation levels of the DMRs were further studied in a panel of near-isogenic lines to evaluate the stable inheritance of the methylation levels and to assess the contribution of cis- and trans- acting information to natural epigenetic variation. The majority of DMRs that occur in genomic regions without genetic variation are controlled by cis-acting differences and exhibit relatively stable inheritance. This study provides evidence for naturally occurring epigenetic variation in maize, including examples of pure epigenetic variation that is not conditioned by genetic differences. The epigenetic differences are variable within maize populations and exhibit relatively stable trans-generational inheritance. The detected examples of epigenetic variation, including some without tightly linked genetic variation, may contribute to complex trait variation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.