ArticleBiomedical microdevices2012
Flexible microelectrode arrays to interface epicardial electrical signals with intracardial calcium transients in zebrafish hearts.
Article in Biomedical microdevices, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Acute severe hypoxia induces prolonged cardiac transcriptomic remodeling despite rapid functional recovery.Research square · 2026Article
- In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025Article
- Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices.BME frontiers · 2023Review
- The Effect of Hypothermia and Osmotic Shock on the Electrocardiogram of Adult Zebrafish.Biology · 2022Article
- A novel wireless ECG system for prolonged monitoring of multiple zebrafish for heart disease and drug screening studies.Biosensors & bioelectronics · 2022Article
- Nano-copper enhanced flexible device for simultaneous measurement of human respiratory and electro-cardiac activities.Journal of nanobiotechnology · 2020Article
- Bioelectronics for Millimeter-Sized Model Organisms.iScience · 2020Review
- A Low Contact Impedance Medical Flexible Electrode Based on a Pyramid Array Micro-Structure.Micromachines · 2020Article
- Acquisition, Processing and Analysis of Electrocardiogram in Awake Zebrafish.IEEE sensors journal · 2019Article
- Biomimetic cardiovascular platforms for in vitro disease modeling and therapeutic validation.Biomaterials · 2019Review
- On Zebrafish Disease Models and Matters of the Heart.Biomedicines · 2019Review
- Development of a rapid and economic in vivo electrocardiogram platform for cardiovascular drug assay and electrophysiology research in adult zebrafish.Scientific reports · 2018Article
- Improvement of surface ECG recording in adult zebrafish reveals that the value of this model exceeds our expectation.Scientific reports · 2016Article
- ModelingJournal of cardiovascular development and disease · 2016Article
- Zebrafish heart as a model for human cardiac electrophysiology.Channels (Austin, Tex.) · 2016Review
- Flexible and waterproof micro-sensors to uncover zebrafish circadian rhythms: The next generation of cardiac monitoring for drug screening.Biosensors & bioelectronics · 2015Article
- Electrical and Mechanical Strategies to Enable Cardiac Repair and Regeneration.IEEE reviews in biomedical engineering · 2015Review
- Wearable multi-channel microelectrode membranes for elucidating electrophysiological phenotypes of injured myocardium.Integrative biology : quantitative biosciences from nano to macro · 2014Article
- Optimisation of embryonic and larval ECG measurement in zebrafish for quantifying the effect of QT prolonging drugs.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The zebrafish (Danio rerio) is an emerging genetic model for regenerative medicine. In humans, myocardial infarction results in the irreversible loss of cardiomyocytes. However, zebrafish hearts fully regenerate after a 20% ventricular resection, without either scarring or arrhythmias. To study this cardiac regeneration, we developed implantable flexible multi-microelectrode membrane arrays that measure the epicardial electrocardiogram signals of zebrafish in real-time. The microelectrode electrical signals allowed for a high level of both temporal and spatial resolution (~20 μm), and the signal to noise ratio of the epicardial ECG was comparable to that of surface electrode ECG (7.1 dB vs. 7.4 dB, respectively). Processing and analysis of the signals from the microelectrode array demonstrated distinct ECG signals: namely, atrial conduction (P waves), ventricular contraction (QRS), and ventricular repolarization (QT interval). The electrical signals were in synchrony with optically measured Calcium concentration gradients in terms of d[Ca²⁺]/dt at both whole heart and tissue levels. These microelectrodes therefore provide a real-time analytical tool for monitoring conduction phenotypes of small vertebral animals with a high temporal and spatial resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.