Evidence map›Paper›PMID 22124858›Full record

ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2012

Evidence for avian cell autonomous sex identity (CASI) and implications for the sex-determination process?

M Clinton, D Zhao, S Nandi, D McBride

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Overview of Avian Sex Reversal.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Sex reversal.Current biology : CB · 2018
    Article
  13. Banding cytogenetics of chimeric hybridsComparative cytogenetics · 2018
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Sex-biased expression of sex-differentiating genes FOXL2 and FGF9 in American alligators, alligator Mississippiensis.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2013
    Article
  19. Article
  20. Are some chromosomes particularly good at sex? Insights from amniotes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

M ClintonDepartment of Developmental Biology, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK. Michael.clinton@ed.ac.uk
D Zhao
S Nandi
D McBride
University of Edinburgh · GBRoslin Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BB/E015425/1Biotechnology and Biological Sciences Research Council BB/E015425/2Biotechnology and Biological Sciences Research Council BB/H012486/1
6 · The paper itself

Abstract

For the majority of animals, males and females are obviously different in terms of appearance, behaviour and physiology, and until recently, these differences were considered to be the result of hormone actions. However, there is now considerable evidence that the development of some sexually dimorphic structures/behaviours is a function of properties inherent to male and female cells (hormone independent). The relative contribution of hormones and cellular identity to the development of the phenotype is not clear and is likely to vary from species to species. The study of gynandromorph birds and chimeric embryos has greatly assisted efforts to distinguish between the effects of hormones and inherent cellular factors on phenotype. It is now clear that in birds, male/female differences are not primarily the result of hormone action and that male and female somatic cells possess a cell autonomous sex identity (CASI). Here, we review evidence for CASI in birds and discuss the implications for the process of sex determination.

Indexed as

Sex Determination ProcessesAnimalsBirdsCell DifferentiationChick EmbryoFemaleGonadsHormonesMaleSex ChromosomesSex-Determining Region Y ProteinSex DifferentiationTranscription FactorsDMRT1 proteinHormonesSex-Determining Region Y ProteinTranscription Factors

Identifiers

PMID22124858
OpenAlexW2080763888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.