ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2012
Inflammatory cytokine profiles in the tears of thyroid-associated ophthalmopathy.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02316691 (B-cell Depletion Therapy With Rituximab for Thyroid Eye Disease), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
B-cell Depletion Therapy With Rituximab for Thyroid Eye Disease
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Systematic review of ocular surface treatments in the setting of thyroid eye disease.Frontiers in ophthalmology · 2024Pooled it
- Magnetic resonance imaging parameters on lacrimal gland in thyroid eye disease: a systematic review and meta-analysis.BMC ophthalmology · 2023Pooled it
- Review
- Changes in corneal and lenticular transparency in active and inactive Graves' Ophthalmopathy: a comparative densitometric study.International ophthalmology · 2026Article
- Exploring tear fluid biomarkers and the ocular surface in thyroid eye disease.Acta ophthalmologica · 2026Article
- Eyelid Malpositions and Ocular Surface Disease: Clinical Correlations and Management Strategies.Journal of clinical medicine · 2025Review
- Research progress on the immune mechanism of thyroid-related eye disease combined with dry eye.Journal of ophthalmic inflammation and infection · 2025Article
- Hashimoto's Thyroiditis and Dry Eye Disease.Journal of clinical medicine · 2025Article
- Selenium: Could It Be the Game-Changer for Ocular Surface and Anterior Chamber in Graves' Disease?Beyoglu eye journal · 2025Article
- Ocular surface and meibomian gland evaluation in euthyroid Graves' ophthalmopathy.International ophthalmology · 2024Article
- Evaluation of the corneal biomechanical properties and corneal thickness in patients with Graves' orbitopathy.International ophthalmology · 2023Article
- Tears as a Source of Biomarkers in the Diagnosis of Graves' Orbitopathy.Biomolecules · 2022Review
- Improvement of Ocular Surface Disease by Lateral Tarsoconjunctival Flap in Thyroid-Associated Orbitopathy Patients with Lid Retraction.Journal of personalized medicine · 2022Article
- Ocular surface disease in thyroid eye disease: A narrative review.The ocular surface · 2022Review
- The value of SPECT/CT imaging of lacrimal glands as a means of assessing the activity of Graves' orbitopathy.Endocrine connections · 2022Article
- In vivo confocal microscopy assessment of meibomian glands microstructure in patients with Graves' orbitopathy.BMC ophthalmology · 2021Article
- Acute Corneal Hydrops in Keratoconus Patients with Graves' Orbitopathy.Beyoglu eye journal · 2021Article
- Mechanisms That Underly T Cell Immunity in Graves' Orbitopathy.Frontiers in endocrinology · 2021Review
- Ocular surface changes in Graves' ophthalmopathy.International journal of ophthalmology · 2021Review
- Tear inflammatory cytokines and ocular surface changes in patients with active thyroid eye disease treated with high-dose intravenous glucocorticoids.Journal of endocrinological investigation · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the levels of seven inflammatory cytokines and one chemokine in tears of patients with thyroid-associated ophthalmopathy (TAO) and asymptomatic control subjects, and determine the correlations between tear inflammatory mediators and clinical parameters.
methodsProspective observational cohort study. The study involved 21 patients with TAO and ten asymptomatic controls. TAO patients were divided into active TAO and inactive TAO on the basis of 7-point modified formulation of the clinical activity score (CAS). Ocular Surface Disease Index (OSDI) score, tear film break-up time (BUT) was obtained, and the Schirmer test and fluorescein staining were performed in all participants. Ten microliters of tears were collected for analysis the concentrations of interleukin (IL)-1β, IL-2, IL-6, IL-10, IL-17 interferon (IFN)-γ, tumor necrosis factor (TNF)-α and one chemokine (IL-8) by multiplex bead analysis.
resultsFluorescein staining scores were higher, BUT scores were shorter, and Schirmer test scores were lower in patients with active TAO and inactive TAO than in control subjects. IL-1β, IL-6, and IL-8 concentrations in tears were significantly higher in active TAO than inactive TAO and the controls. TNF-α concentration was significantly higher in both active and inactive TAO compared with the controls. IL-17 was significantly higher in active TAO than the controls, and the level of IL-2 was significantly higher in inactive TAO compared with the controls. There were significantly positive correlations between tear IL-1β, IL-6 and IL-8 levels and CAS in TAO. No significant correlations were found between other cytokine concentrations and clinical parameters in TAO.
conclusionsThe differences of tear inflammatory cytokines between patients with active and inactive TAO indicated that orbital inflammation may be involved in the ocular surface damage of TAO.
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Registered trials
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