ArticleDiabetes care2012
Associations of gestational diabetes, existing diabetes, and glycosuria with offspring obesity and cardiometabolic outcomes.
Article in Diabetes care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- How Do the Different Types of Maternal Diabetes during Pregnancy Influence Offspring Outcomes?Nutrients · 2022Pooled it
- Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis.The Lancet. Child & adolescent health · 2018Pooled it
- Obesity and abnormal glucose tolerance in offspring of diabetic mothers: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Prenatal factors shaping adolescent cardiovascular function and cardiometabolic risk trajectories.Frontiers in pediatrics · 2026Review
- The Adverse Influence of Maternal Glycaemia During Pregnancy on Offspring's Cardiometabolic Health Profiles.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Prediction of gestational diabetes mellitus by multiple biomarkers at early gestation.BMC pregnancy and childbirth · 2024Article
- Decreased telomerase activity and shortened telomere length in infants whose mothers have gestational diabetes mellitus and increased severity of telomere shortening in male infants.Frontiers in endocrinology · 2024Article
- Low Apgar score and asphyxia complications at birth and risk of longer-term cardiovascular disease: a nationwide population-based study of term infants.The Lancet regional health. Europe · 2023Article
- Maternal GDM Status, Genetically Determined Blood Glucose, and Offspring Obesity Risk: An Observational Study.Obesity (Silver Spring, Md.) · 2021Observational
- Maternal and gestational influences on childhood blood pressure.Pediatric nephrology (Berlin, Germany) · 2020Article
- Common variation at 16p11.2 is associated with glycosuria in pregnancy: findings from a genome-wide association study in European women.Human molecular genetics · 2020Article
- Maternal Glycemia During Pregnancy and Child Carotid Intima Media Thickness, Pulse Wave Velocity, and Augmentation Index.The Journal of clinical endocrinology and metabolism · 2020Article
- The Joint Associations of Maternal BMI and Glycemia with Childhood Adiposity.The Journal of clinical endocrinology and metabolism · 2020Article
- Maternal Glucose Concentrations in Early Pregnancy and Cardiometabolic Risk Factors in Childhood.Obesity (Silver Spring, Md.) · 2020Article
- Gestational Diabetes Mellitus and the Long-Term Risk for Glucose Intolerance and Overweight in the Offspring: A Narrative Review.Journal of clinical medicine · 2020Review
- Hyperglycaemia in Pregnancy and Anthropometric Parameters in the Offspring at 10 Years: A Community-Based Retrospective Cohort Study in Sri Lanka.Journal of obesity · 2020Article
- The Sex Specific Association Between Maternal Gestational Diabetes and Offspring Metabolic Status at 1 Year of Age.Frontiers in endocrinology · 2020Article
- Maternal glucose levels during pregnancy and childhood adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study.Diabetologia · 2019Observational
- Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children.JCI insight · 2018Article
- Telomere length is reduced in 9- to 16-year-old girls exposed to gestational diabetes in utero.Diabetologia · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo assess associations of gestational diabetes, existing diabetes, and glycosuria with adiposity and cardiometabolic risk factors in offspring at adolescence. RESEARCH DESIGN AND
methodsMultivariable regression analyses were conducted in a prospective pregnancy cohort (n = 2,563-4,198 for different outcomes). Obstetric data were abstracted from clinical records. Offspring outcomes were assessed at mean age 15.5 years. Compared with those lost to follow-up, participants included in the analysis were of higher socioeconomic position. Outcomes included BMI, waist circumference, fat mass determined by dual-energy X-ray absorptiometry scan, systolic and diastolic blood pressure (sBP and dBP, respectively), fasting glucose, insulin, lipids, and C-reactive protein (CRP).
resultsMaternal existing diabetes, gestational diabetes, and glycosuria were associated with higher offspring BMI and fat mass (z scores); however, this effect was attenuated in the confounder-adjusted model, and the CIs included the null value. Existing diabetes and gestational diabetes were associated with higher offspring fasting glucose levels (0.24 mmol/L [95% CI 0.03-0.45] and 0.20 mmol/L [0.02-0.39], respectively). Glycosuria was associated with higher fasting insulin (adjusted ratio of geometric means 1.12 [1.01-1.25]), but there were no clear associations of existing or gestational diabetes with offspring fasting insulin. There was little evidence of an association of maternal diabetes or glycosuria with offspring dBP, sBP, lipids, or CRP.
conclusionsMaternal pregnancy glycosuria, gestational diabetes, and existing diabetes show some associations with higher offspring fasting glucose and insulin assessed in adolescence but are not clearly associated with a wider range of cardiometabolic risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.