ArticleThe EMBO journal2012
Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans.
Article in The EMBO journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 83 citations in OpenAlex.
- Starvation transforms signal encoding ineLife · 2026Article
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- Hungry for Knowledge: Octopamine Signaling Regulates Hunger-Enhanced Olfactory Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nuclear receptor-neurotransmitter coupling links behavior to metabolic state.bioRxiv : the preprint server for biology · 2025Article
- Loss of neuropeptidergic regulation of cholinergic transmission induces homeostatic compensation in muscle cells to preserve synaptic strength.PLoS biology · 2025Article
- TheiScience · 2025Article
- Behavioral adjustment of C. elegans to mechanosensory loss requires intact mechanosensory neurons.PLoS biology · 2024Article
- Neuromolecular mechanisms related to reflex behaviour inRoyal Society open science · 2024Article
- Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans.Molecular and cellular endocrinology · 2024Article
- Alleviation of thermal nociception depends on heat-sensitive neurons and a TRP channel in the brain.Current biology : CB · 2023Article
- Regulation and modulation of biogenic amine neurotransmission inFrontiers in physiology · 2023Review
- Culturomic-, metagenomic-, and transcriptomic-based characterization of commensal lactic acid bacteria isolated from domestic dogs using Caenorhabditis elegans as a model for aging.Journal of animal science · 2022Article
- Positive interaction between ASH and ASK sensory neurons accelerates nociception and inhibits behavioral adaptation.iScience · 2022Article
- Reduced CaFrontiers in neuroscience · 2022Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- Calcium Imaging of Neuronal Activity under Gradually Changing Odor Stimulation inBio-protocol · 2021Article
- Article
- Article
- Co-option of neurotransmitter signaling for inter-organismal communication in C. elegans.Nature communications · 2019Article
- Sexually Dimorphic Regulation of Behavioral States by Dopamine inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Pain modulation is complex, but noradrenergic signalling promotes anti-nociception, with α(2)-adrenergic agonists used clinically. To better understand the noradrenergic/peptidergic modulation of nociception, we examined the octopaminergic inhibition of aversive behaviour initiated by the Caenorhabditis elegans nociceptive ASH sensory neurons. Octopamine (OA), the invertebrate counterpart of norepinephrine, modulates sensory-mediated reversal through three α-adrenergic-like OA receptors. OCTR-1 and SER-3 antagonistically modulate ASH signalling directly, with OCTR-1 signalling mediated by Gα(o). In contrast, SER-6 inhibits aversive responses by stimulating the release of an array of 'inhibitory' neuropeptides that activate receptors on sensory neurons mediating attraction or repulsion, suggesting that peptidergic signalling may integrate multiple sensory inputs to modulate locomotory transitions. These studies highlight the complexity of octopaminergic/peptidergic interactions, the role of OA in activating global peptidergic signalling cascades and the similarities of this modulatory network to the noradrenergic inhibition of nociception in mammals, where norepinephrine suppresses chronic pain through inhibitory α(2)-adrenoreceptors on afferent nociceptors and stimulatory α(1)-receptors on inhibitory peptidergic interneurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.