Evidence map›Paper›PMID 22124031›Full record

Trial reportRestorative neurology and neuroscience2011

Optimizing recovery potential through simultaneous occupational therapy and non-invasive brain-stimulation using tDCS.

Dinesh G Nair, Vijay Renga, Robert Lindenberg, Lin Zhu, Gottfried Schlaug

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Restorative neurology and neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 11 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 11 syntheses or guidelines pooled it, 158 citations in OpenAlex.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dinesh G NairDepartment of Neurology, Neuroimaging and Stroke Recovery Laboratories, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA 02215, USA.
Vijay Renga
Robert Lindenberg
Lin Zhu
Gottfried Schlaug
Harvard University · USBeth Israel Deaconess Medical Center · US

Funding

Behavioral and Neural Correlates of Melodic Intonation TherapyR01DC008796 · NIDCD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCHLAUG, GOTTFRIED · 2008 to 2012
$2.0M
Facilitators of Motor Recovery Following StrokeR01NS045049 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCHLAUG, GOTTFRIED · 2004 to 2007
$1.3M
NIDCD NIH HHS R01 DC008796NIDCD NIH HHS R01DC008796NINDS NIH HHS R01 NS045049
6 · The paper itself

Abstract

purposeIt is thought that following a stroke the contralesional motor region exerts an undue inhibitory influence on the lesional motor region which might limit recovery. Pilot studies have shown that suppressing the contralesional motor region with cathodal transcranial Direct Current Stimulation (tDCS) can induce a short lasting functional benefit; greater and longer lasting effects might be achieved with combining tDCS with simultaneous occupational therapy (OT) and applying this intervention for multiple sessions.

methodsWe carried out a randomized, double blind, sham controlled study of chronic stroke patients receiving either 5 consecutive days of cathodal tDCS (for 30 minutes) applied to the contralesional motor region and simultaneous OT, or sham tDCS+OT.

resultswe showed that cathodal tDCS+OT resulted in significantly more improvement in Range-Of-Motion in multiple joints of the paretic upper extremity and in the Upper-Extremity Fugl-Meyer scores than sham tDCS+OT, and that the effects lasted at least one week post-stimulation. Improvement in motor outcome scores was correlated with decrease in fMRI activation in the contralesional motor region exposed to cathodal stimulation.

conclusionsThis suggests that cathodal tDCS combined with OT leads to significant motor improvement after stroke due to a decrease in the inhibitory effect that the contralesional hemisphere exerts onto the lesional hemisphere.

Indexed as

AdultAgedDouble-Blind MethodElectrodesFemaleFunctional LateralityHumansImage Processing, Computer-AssistedLinear ModelsMagnetic Resonance ImagingMaleMiddle AgedMotor CortexOccupational TherapyOxygenRange of Motion, ArticularOxygen

Identifiers

PMID22124031
PMCPMC4425274
OpenAlexW1762442757

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.