ArticleCerebral cortex (New York, N.Y. : 1991)2012
Robo4 regulates the radial migration of newborn neurons in developing neocortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- How Growth Cones Sense Extracellular Cues and Drive Neuronal Migration: Shared Mechanisms Between Growth Cones of Migrating Neurons and Axons.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- The Slit-Robo signalling pathway in nervous system development: a comparative perspective from vertebrates and invertebrates.Open biology · 2025Review
- Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug delivery and potentiates chemotherapy in GBM.Science advances · 2025Article
- Tissue-Specific Roles for the Slit-Robo Pathway During Heart, Caval Vein, and Diaphragm Development.Journal of the American Heart Association · 2022Article
- Role of Slit/Robo Signaling pathway in Bone Metabolism.International journal of biological sciences · 2022Review
- Single-Cell RNA Sequencing Characterizes the Molecular Heterogeneity of the Larval Zebrafish Optic Tectum.Frontiers in molecular neuroscience · 2022Article
- Article
- Acute and endothelial-specific Robo4 deletion affect hematopoietic stem cell trafficking independent of VCAM1.PloS one · 2021Article
- Genetic Mechanisms Underlying Cortical Evolution in Mammals.Frontiers in cell and developmental biology · 2021Review
- Beyond Axon Guidance: Roles of Slit-Robo Signaling in Neocortical Formation.Frontiers in cell and developmental biology · 2020Review
- Minimal structural elements required for midline repulsive signaling and regulation of Drosophila Robo1.PloS one · 2020Article
- Review
- Toward a Better Understanding of Neuronal Migration Deficits in Autism Spectrum Disorders.Frontiers in cell and developmental biology · 2019Review
- The Role of the Slit/Robo Signaling Pathway.Journal of Cancer · 2019Review
- Meningeal Bmps Regulate Cortical Layer Formation.Brain plasticity (Amsterdam, Netherlands) · 2018Article
- High-throughput three-dimensional chemotactic assays reveal steepness-dependent complexity in neuronal sensation to molecular gradients.Nature communications · 2018Article
- Making Connections: Guidance Cues and Receptors at Nonneural Cell-Cell Junctions.Cold Spring Harbor perspectives in biology · 2018Review
- Clinical relevance of lysyl oxidase-like 2 and functional mechanisms in glioma.OncoTargets and therapy · 2018Article
- Psychiatric behaviors associated with cytoskeletal defects in radial neuronal migration.Cellular and molecular life sciences : CMLS · 2017Review
- Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins.Molecular brain · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the morphogenesis of neocortex, newborn neurons undergo radial migration from the ventricular zone toward the surface of the cortical plate to form an "inside-out" lamina structure. The spatiotemporal signals that control this stereotyped radial migration remain elusive. Here, we report that a recently identified Robo family member Robo4 (Magic Roundabout), which was considered to be solely expressed in endothelial cells, is expressed in developing brain and regulates the radial migration of newborn neurons in neocortex. Downregulation of Robo4 expression in cortical newborn neurons by using in utero electroporation, with either specific siRNAs in wild-type rodents or with Cre recombinase in floxed-robo4 mutant mice, led to severe defects in the radial migration of newborn neurons with misorientation of these neurons. Moreover, newborn neurons transfected with Robo4 siRNAs exhibited significantly lower motility in a transwell migration assay (Boyden chamber) in the absence of Slit and significantly higher sensitivity to the repulsive effect of Slit in both transwell migration assay and growth cone collapse assay. Overall, our results showed an important role of Robo4 in the regulation of cortical radial migration through Slit-dependent and -independent mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.