ArticleThe Journal of cell biology2011
Myosin concentration underlies cell size-dependent scalability of actomyosin ring constriction.
Article in The Journal of cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- CHI3L1 promotes cell division through activation of RhoA in lung cancer cells.Cell communication and signaling : CCS · 2025Article
- Three types of actomyosin rings within a common cytoplasm exhibit distinct modes of contractility.Molecular biology of the cell · 2025Article
- Three types of actomyosin rings within a common cytoplasm exhibit distinct modes of contractility.bioRxiv : the preprint server for biology · 2025Article
- Mechanical and biochemical feedback combine to generate complex contractile oscillations in cytokinesis.Current biology : CB · 2024Article
- Article
- Cell size and polarization determine cytokinesis furrow ingression dynamics in mouse embryos.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Myosin-II proteins are involved in the growth, morphogenesis, and virulence of the human pathogenic fungusFrontiers in cellular and infection microbiology · 2022Article
- Ventral stress fibers induce plasma membrane deformation in human fibroblasts.Molecular biology of the cell · 2021Article
- Cleavage-furrow formation without F-actin inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cell size sets the diameter of the budding yeast contractile ring.Nature communications · 2020Article
- Molecular Mechanism of Cytokinesis.Annual review of biochemistry · 2019Review
- A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis ineLife · 2018Article
- Specific detection of fission yeast primary septum reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion.PLoS genetics · 2018Article
- Fission yeast Myo2: Molecular organization and diffusion in the cytoplasm.Cytoskeleton (Hoboken, N.J.) · 2018Article
- Actin turnover maintains actin filament homeostasis during cytokinetic ring contraction.The Journal of cell biology · 2017Article
- Myosin Clusters of Finite Size Develop Contractile Stress in 1D Random Actin Arrays.Biophysical journal · 2017Article
- Elucidating the molecular mechanisms underlying cellular response to biophysical cues using synthetic biology approaches.Cell adhesion & migration · 2016Review
- Actomyosin contraction, aggregation and traveling waves in a treadmilling actin array.Physica D. Nonlinear phenomena · 2016Article
- Hyphal ontogeny inF1000Research · 2016Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eukaryotes, cytokinesis is accomplished by an actomyosin-based contractile ring. Although in Caenorhabditis elegans embryos larger cells divide at a faster rate than smaller cells, it remains unknown whether a similar mode of scalability operates in other cells. We investigated cytokinesis in the filamentous fungus Neurospora crassa, which exhibits a wide range of hyphal circumferences. We found that N. crassa cells divide using an actomyosin ring and larger rings constricted faster than smaller rings. However, unlike in C. elegans, the total amount of myosin remained constant throughout constriction, and there was a size-dependent increase in the starting concentration of myosin in the ring. We predict that the increased number of ring-associated myosin motors in larger rings leads to the increased constriction rate. Accordingly, reduction or inhibition of ring-associated myosin slows down the rate of constriction. Because the mechanical characteristics of contractile rings are conserved, we predict that these findings will be relevant to actomyosin ring constriction in other cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.