ArticleBlood2012
Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development.
Article in Blood, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
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- Exosomal Long Noncoding RNAs in NSCLC: Dysfunctions and Clinical Potential.Journal of Cancer · 2023Review
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- Tumour-derived exosomal lncRNA-SOX2OT promotes bone metastasis of non-small cell lung cancer by targeting the miRNA-194-5p/RAC1 signalling axis in osteoclasts.Cell death & disease · 2021Article
- AnJBMR plus · 2021Article
- The Rho GTPase RAC1 in Osteoblasts Controls Their Function.International journal of molecular sciences · 2020Article
- Article
- RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment.NPJ microgravity · 2017Article
- Article
- Role of Cbl-PI3K Interaction during Skeletal Remodeling in a Murine Model of Bone Repair.PloS one · 2015Article
- RhoGTPases as key players in mammalian cell adaptation to microgravity.BioMed research international · 2015Review
- p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment.Leukemia · 2013Article
- Rac1 and Cdc42 GTPases regulate shear stress-driven β-catenin signaling in osteoblasts.Biochemical and biophysical research communications · 2013Article
- Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells.Biochemical pharmacology · 2013Article
- The regulation of normal and leukemic hematopoietic stem cells by niches.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2012Article
- SPARC is dispensable for murine hematopoiesis, despite its suspected pathophysiological role in 5q-myelodysplastic syndrome.Leukemia · 2012Article
- Myelodysplastic syndromes: revisiting the role of the bone marrow microenvironment in disease pathogenesis.International journal of hematology · 2012Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Hematopoietic stem cells (HSCs) interact with osteoblastic, stromal, and vascular components of the BM hematopoietic microenvironment (HM) that are required for the maintenance of long-term self-renewal in vivo. Osteoblasts have been reported to be a critical cell type making up the HSC niche in vivo. Rac1 GTPase has been implicated in adhesion, spreading, and differentiation of osteoblast cell lines and is critical for HSC engraftment and retention. Recent data suggest a differential role of GTPases in endosteal/osteoblastic versus perivascular niche function. However, whether Rac signaling pathways are also necessary in the cell-extrinsic control of HSC function within the HM has not been examined. In the present study, genetic and inducible models of Rac deletion were used to demonstrate that Rac depletion causes impaired proliferation and induction of apoptosis in the OP9 cell line and in primary BM stromal cells. Deletion of Rac proteins caused reduced trabecular and cortical long bone growth in vivo. Surprisingly, HSC function and maintenance of hematopoiesis in vivo was preserved despite these substantial cell-extrinsic changes. These data have implications for therapeutic strategies to target Rac signaling in HSC mobilization and in the treatment of leukemia and provide clarification to our evolving concepts of HSC-HM interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.