ArticleAntimicrobial agents and chemotherapy2012
Evolution of IncA/C blaCMY-₂-carrying plasmids by acquisition of the blaNDM-₁ carbapenemase gene.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
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Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Review and analysis of the overlapping threats of carbapenem and polymyxin resistant E. coli and Klebsiella in Africa.Antimicrobial resistance and infection control · 2023Pooled it
- National genomic surveillance reveals global plasmid and chromosomal dissemination routes of blanpj antimicrobials and resistance · 2026Article
- TraN variants mediate conjugation species specificity of IncA/C, IncH, andJournal of bacteriology · 2026Article
- The Emergence ofAntibiotics (Basel, Switzerland) · 2025Article
- Healthcare-related transmission of mobile genetic elements co-carryingMicrobial genomics · 2025Article
- Genomic characterization of plasmids harboringMicrobiology spectrum · 2025Article
- Assessing the threat ofAntimicrobial agents and chemotherapy · 2025Article
- Co-occurrence of mcr-9 and blaCurrent microbiology · 2025Article
- Article
- IncC plasmid genome rearrangements influence the vertical and horizontal transmission tradeoff inAntimicrobial agents and chemotherapy · 2024Article
- Molecular Analysis of Carbapenem and Aminoglycoside Resistance Genes in Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes.Frontiers in cellular and infection microbiology · 2024Review
- Molecular Characterization of a KPC-2- and NDM-1-ProducingInfection and drug resistance · 2024Article
- Identification of IncA Plasmid, HarboringAntibiotics (Basel, Switzerland) · 2023Article
- Clonal, Plasmidic and Genetic Diversity of Multi-Drug-Resistant Enterobacterales from Hospitalized Patients in Tripoli, Libya.Antibiotics (Basel, Switzerland) · 2023Article
- Genomic analyses of drug-resistant Salmonella enterica serovar Heidelberg strains isolated from meat and related sources between 2013 and 2017 in the south region of Brazil.Current genetics · 2023Article
- Genome-Based Retrospective Analysis of aAntibiotics (Basel, Switzerland) · 2023Article
- Diversity of Bacterial Clones and Plasmids of NDM-1 ProducingMicroorganisms · 2023Article
- A Broad-Host-Range Plasmid Outbreak: Dynamics of IncL/M Plasmids Transferring Carbapenemase Genes.Antibiotics (Basel, Switzerland) · 2022Article
- Prevalence and Molecular Typing of Carbapenemase-Producing Enterobacterales among Newborn Patients in Italy.Antibiotics (Basel, Switzerland) · 2022Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bla(NDM-1) gene has been reported to be often located on broad-host-range plasmids of the IncA/C type in clinical but also environmental bacteria recovered from the New Delhi, India, area. IncA/C-type plasmids are the main vehicles for the spread of the cephalosporinase gene bla(CMY-2), frequently identified in the United States, Canada, and Europe. In this study, we completed the sequence of IncA/C plasmid pNDM-KN carrying the bla(NDM-1) gene, recovered from a Klebsiella pneumoniae isolate from Kenya. This sequence was compared with those of three IncA/C-type reference plasmids from Escherichia coli, Yersinia ruckeri, and Photobacterium damselae. Comparative analysis showed that the bla(NDM-1) gene was located on a widely diffused plasmid scaffold known to be responsible for the spread of bla(CMY-2)-like genes and consequently for resistance to broad-spectrum cephalosporins. Considering that IncA/C plasmids possess a broad host range, this scaffold might support a large-scale diffusion of the bla(NDM-1) gene among Gram-negative rods.
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