Evidence map›Paper›PMID 22123296›Full record

ReviewMicrobes and infection2012

A battle for iron: host sequestration and Staphylococcus aureus acquisition.

Kathryn P Haley, Eric P Skaar

Abstract readReview
In one paragraph

Review in Microbes and infection, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed.

  1. Article
  2. Article
  3. Host-driven remodelling of theMicrobiology (Reading, England) · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. The Pathogenicity Mechanisms ofInternational journal of molecular sciences · 2025
    Review
  8. Review
  9. Genomic epidemiology and characterization ofFrontiers in microbiology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Subpopulations in Strains ofAntibiotics (Basel, Switzerland) · 2023
    Review
  19. Review
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kathryn P HaleyDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21st Ave., South, A5102 MCN, Nashville, TN 37232-2363, USA.
Eric P Skaar

Funding

Yessinia autotransporters (Yaps): Structure, function, and host responseU54AI057157 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CROWE, JAMES E · 2003 to 2013
$91.4M
Pathobiology of heme inducible transporters in Gram positive pathogensR01AI073843 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2009 to 2025
$5.9M
Mechanism and function of heme-iron utilization in staphylococcal pathogenesisR01AI069233 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2006 to 2020
$5.6M
NIAID NIH HHS AI0169233NIAID NIH HHS AI057157NIAID NIH HHS AI073843NIAID NIH HHS R01 AI069233NIAID NIH HHS R01 AI073843NIAID NIH HHS U54 AI057157PHS HHS 5 T32 A107611-10
6 · The paper itself

Abstract

The use of iron as an enzymatic cofactor is pervasive in biological systems. Consequently most living organisms, including pathogenic bacteria, require iron to survive and replicate. To combat infection vertebrates have evolved sophisticated iron sequestration systems against which, pathogenic bacteria have concomitantly evolved equally elaborate iron acquisition mechanisms.

Indexed as

AnimalsBacterial ProteinsGene Expression Regulation, BacterialHemeHeme Oxygenase (Decyclizing)HemoglobinsHost-Pathogen InteractionsHumansIronSiderophoresStaphylococcal InfectionsStaphylococcus aureusVirulence FactorsBacterial ProteinsHemeHeme Oxygenase (Decyclizing)HemoglobinsIronSiderophoresVirulence Factors

Identifiers

PMID22123296
PMCPMC3785375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.