ArticleJournal of bacteriology2012
LytF, a novel competence-regulated murein hydrolase in the genus Streptococcus.
Article in Journal of bacteriology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Genetic and functional characterization of the natural transformation system inMicrobiology (Reading, England) · 2026Article
- LytF contributes to pilus extrusion during natural competence inJournal of bacteriology · 2026Article
- Colocalisation of lanthipeptide production with genetic exchange and defence systems across prokaryote genomes.BMC genomics · 2025Article
- LytF contributes to pilus extrusion during natural competence inbioRxiv : the preprint server for biology · 2025Article
- Functional and Genomic Insights into the Biotechnological Potential of Vibrio spp. Isolated from Deeply Polluted and Pristine Environments.Current microbiology · 2024Article
- Investigation of choline-binding protein of CbpD in the pathogenesis ofFrontiers in veterinary science · 2024Article
- CrfP, a fratricide protein, contributes to natural transformation in Streptococcus suis.Veterinary research · 2021Article
- Competence-Stimulating-Peptide-Dependent Localized Cell Death and Extracellular DNA Production in Streptococcus mutans Biofilms.Applied and environmental microbiology · 2020Article
- Harnessing the Potential of Killers and Altruists within the Microbial Community: A Possible Alternative to Antibiotic Therapy?Antibiotics (Basel, Switzerland) · 2019Review
- High-resolution profiles of the Streptococcus mitis CSP signaling pathway reveal core and strain-specific regulated genes.BMC genomics · 2018Article
- Murein Hydrolase LytF of Streptococcus sanguinis and the Ecological Consequences of Competence Development.Applied and environmental microbiology · 2017Article
- The molecular mechanism ofThe Journal of biological chemistry · 2017Article
- Interbacterial predation as a strategy for DNA acquisition in naturally competent bacteria.Nature reviews. Microbiology · 2017Review
- Classic Spotlight: the Physiological State of Competence and So Much More.Journal of bacteriology · 2016Article
- The impact of horizontal gene transfer on the adaptive ability of the human oral microbiome.Frontiers in cellular and infection microbiology · 2014Review
- Cell death of Streptococcus mutans induced by a quorum-sensing peptide occurs via a conserved streptococcal autolysin.Journal of bacteriology · 2013Article
- Article
- Fratricide is essential for efficient gene transfer between pneumococci in biofilms.Applied and environmental microbiology · 2012Article
- Properties and biological role of streptococcal fratricins.Applied and environmental microbiology · 2012Review
- The role of hydrogen peroxide in environmental adaptation of oral microbial communities.Oxidative medicine and cellular longevity · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus pneumoniae and probably most other members of the genus Streptococcus are competent for natural genetic transformation. During the competent state, S. pneumoniae produces a murein hydrolase, CbpD, that kills and lyses noncompetent pneumococci and closely related species. Previous studies have shown that CbpD is essential for efficient transfer of genomic DNA from noncompetent to competent cells in vitro. Consequently, it has been proposed that CbpD together with the cognate immunity protein ComM constitutes a DNA acquisition mechanism that enables competent pneumococci to capture homologous DNA from closely related streptococci sharing the same habitat. Although genes encoding CbpD homologs or CbpD-related proteins are present in many different streptococcal species, the genomes of a number of streptococci do not encode CbpD-type proteins. In the present study we show that the genomes of nearly all species lacking CbpD encode an unrelated competence-regulated murein hydrolase termed LytF. Using Streptococcus gordonii as a model system, we obtained evidence indicating that LytF is a functional analogue of CbpD. In sum, our results show that a murein hydrolase gene is part of the competence regulon of most or all streptococcal species, demonstrating that these muralytic enzymes constitute an essential part of the streptococcal natural transformation system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.