Trial reportNoise & health
Increased vitamin plasma levels in Swedish military personnel treated with nutrients prior to automatic weapon training.
Trial report in Noise & health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00808470 (Micronutrient Intervention to Reduce Noise-Induced Hearing Loss), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Micronutrient Intervention to Reduce Noise-Induced Hearing Loss: Prevention of Temporary Threshold Changes Induced by Use of a Digital Music Player
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Protective effects of vitamins/antioxidants on occupational noise-induced hearing loss: A systematic review.Journal of occupational health · 2021Pooled it
- A randomised, double blind trial of N-Acetylcysteine for hearing protection during stapes surgery.PloS one · 2015Trial
- Trial
- Limited Link of Common Blood Parameters with Tinnitus.Journal of clinical medicine · 2023Article
- Review
- Noise-induced hearing disorders: Clinical and investigational tools.The Journal of the Acoustical Society of America · 2023Article
- Prevention of Noise-Induced Hearing Loss Using Investigational Medicines for the Inner Ear: Previous Trial Outcomes Should Inform Future Trial Design.Antioxidants & redox signaling · 2022Review
- Disease Prevention and Treatment Using β-Carotene: the Ultimate Provitamin A.Revista brasileira de farmacognosia : orgao oficial da Sociedade Brasileira de Farmacognosia · 2022Review
- Evaluation of hidden hearing loss in normal-hearing firearm users.Frontiers in neuroscience · 2022Article
- Effect of myricetin on the gene expressions of NOX3, TGF-β1, prestin, and HSP-70 and anti-oxidant activity in the cochlea of noise-exposed rats.Iranian journal of basic medical sciences · 2020Article
- Noise-induced hearing loss and its prevention: Integration of data from animal models and human clinical trials.The Journal of the Acoustical Society of America · 2019Review
- Translating animal models to human therapeutics in noise-induced and age-related hearing loss.Hearing research · 2019Review
- Otoprotectants: From Research to Clinical Application.Seminars in hearing · 2019Review
- Hidden Hearing Loss? No Effect of Common Recreational Noise Exposure on Cochlear Nerve Response Amplitude in Humans.Frontiers in neuroscience · 2017Article
- A polymorphism in human estrogen-related receptor beta (ESRRβ) predicts audiometric temporary threshold shift.International journal of audiology · 2016Article
- Early investigational drugs for hearing loss.Expert opinion on investigational drugs · 2015Review
- Associations between dietary quality, noise, and hearing: data from the National Health and Nutrition Examination Survey, 1999-2002.International journal of audiology · 2014Article
- Temporary threshold shift after impulse-noise during video game play: laboratory data.International journal of audiology · 2014Article
- Impact of the ACEMg Biomedicine on Sensorineural Hearing Loss and Auditory Function: Analysis of Real-World Clinical Data.Global advances in integrative medicine and healthArticle
- Dietary supplement comprised of β-carotene, vitamin C, vitamin E, and magnesium: failure to prevent music-induced temporary threshold shift.Audiology and neurotology. ExtraArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Noise-induced hearing loss (NIHL) is a significant clinical, social, and economic issue. The development of novel therapeutic agents to reduce NIHL will potentially benefit multiple very large noise-exposed populations. Oxidative stress has been identified as a significant contributor to noise-induced sensory cell death and NIHL, and several antioxidant strategies have now been suggested for potential translation to human subjects. One such strategy is a combination of beta-carotene, vitamins C and E, and magnesium, which has shown promise for protection against NIHL in rodent models, and is being evaluated in a series of international human clinical trials using temporary (military gunfire, audio player use) and permanent (stamping factory, military airbase) threshold shift models (NCT00808470). The noise exposures used in the recently completed Swedish military gunfire study described in this report did not, on average, result in measurable changes in auditory function using conventional pure-tone thresholds and distortion product otoacoustic emission (DPOAE) amplitudes as metrics. However, analysis of the plasma samples confirmed significant elevations in the bloodstream 2 hours after oral consumption of active clinical supplies, indicating the dose is realistic. The plasma outcomes are encouraging, but clinical acceptance of any novel therapeutic critically depends on demonstration that the agent reduces noise-induced threshold shift in randomized, placebo-controlled, prospective human clinical trials. Although this noise insult did not induce hearing loss, the trial design and study protocol can be applied to other populations exposed to different noise insults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.