Evidence map›Paper›PMID 22122927›Full record

ReviewAnalytica chimica acta2012

Protein separation by capillary gel electrophoresis: a review.

Zaifang Zhu, Joann J Lu, Shaorong Liu

Abstract readReview
In one paragraph

Review in Analytica chimica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 205 citations in OpenAlex.

  1. Review
  2. Capillary Gradient Gel Electrophoresis.Gels (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Regulatory Guidelines for the Analysis of Therapeutic Peptides and Proteins.Journal of peptide science : an official publication of the European Peptide Society · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zaifang ZhuDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, United States.
Joann J Lu
Shaorong Liu
University of Oklahoma · US

Funding

Hybrid Chip Device for Automated 2-D Protein SeparationR01GM078592 · NIGMS · UNIVERSITY OF OKLAHOMA · PI LIU, SHAORONG · 2006 to 2010
$1.5M
NIGMS NIH HHS R01 GM078592
6 · The paper itself

Abstract

Capillary gel electrophoresis (CGE) has been used for protein separation for more than two decades. Due to the technology advancement, current CGE methods are becoming more and more robust and reliable for protein analysis, and some of the methods have been routinely used for the analysis of protein-based pharmaceuticals and quality controls. In light of this progress, we survey 147 papers related to CGE separations of proteins and present an overview of this technology. We first introduce briefly the early development of CGE. We then review the methodology, in which we specifically describe the matrices, coatings, and detection strategies used in CGE. CGE using microfabricated channels and incorporation of CGE with two-dimensional protein separations are also discussed in this section. We finally present a few representative applications of CGE for separating proteins in real-world samples.

Indexed as

Electrophoresis, CapillaryElectrophoresis, Gel, Two-DimensionalImmunoblottingProteinsSpectrophotometry, UltravioletProteins

Identifiers

PMID22122927
PMCPMC3227876
OpenAlexW2039108689

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.