ArticleNanoscale research letters2011
Functionalized halloysite nanotube-based carrier for intracellular delivery of antisense oligonucleotides.
Article in Nanoscale research letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed.
- Prenatal and maternal study of halloysite toxicity in pregnant rats.Scientific reports · 2025Article
- Therapeutic Oligonucleotides for Neurodegenerative Diseases: Aptamer Strategies and Clay Nanoparticle-Based Delivery.Chemical record (New York, N.Y.) · 2025Review
- PEG-modified halloysite as a hydrophilic interaction and cation exchange mixed-mode sorbent for solid-phase extraction of biogenic amines in fish samples.Analytical and bioanalytical chemistry · 2023Article
- Halloysite Nanotubes and Sepiolite for Health Applications.International journal of molecular sciences · 2023Review
- Spectrophotometric and nucleic acid-binding properties of halloysite clay nanotubes and kaolinite.Heliyon · 2023Article
- Nano-Clays for Cancer Therapy: State-of-the Art and Future Perspectives.Journal of personalized medicine · 2022Review
- Nanoclays in medicine: a new frontier of an ancient medical practice.Materials advances · 2022Review
- DNA interfaces with dimensional materials for biomedical applications.RSC advances · 2021Review
- The in vitro toxicity evaluation of halloysite nanotubes (HNTs) in human lung cells.Toxicological research · 2021Article
- Application of Halloysite Nanotubes in Cancer Therapy-A Review.Materials (Basel, Switzerland) · 2021Review
- Chitosan-Coated Halloysite Nanotubes As Vehicle for Controlled Drug Delivery to MCF-7 Cancer Cells In Vitro.Materials (Basel, Switzerland) · 2021Article
- Antibody-Functionalized Halloysite Nanotubes for Targeting Bacterial Cells.ACS applied bio materials · 2021Article
- Infrared Nanospectroscopy Reveals DNA Structural Modifications upon Immobilization onto Clay Nanotubes.Nanomaterials (Basel, Switzerland) · 2021Article
- Past, Present and Future Perspectives on Halloysite Clay Minerals.Molecules (Basel, Switzerland) · 2020Review
- Cellular Analysis and Chemotherapeutic Potential of a Bi-Functionalized Halloysite Nanotube.Pharmaceutics · 2020Article
- An Approach for Magnetic Halloysite Nanocomposite with Selective Loading of Superparamagnetic Magnetite Nanoparticles in the Lumen.Inorganic chemistry · 2020Article
- Facile Fabrication of Natural Polyelectrolyte-Nanoclay Composites: Halloysite Nanotubes, Nucleotides and DNA Study.Molecules (Basel, Switzerland) · 2020Article
- Article
- Evolution of Hair Treatment and Care: Prospects of Nanotube-Based Formulations.Nanomaterials (Basel, Switzerland) · 2019Article
- Advances in Halloysite Nanotubes-Polysaccharide Nanocomposite Preparation and Applications.Polymers · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Halloysites are cheap, abundantly available, and natural with high mechanical strength and biocompatibility. In this paper, a novel halloysite nanotube [HNT]-based gene delivery system was explored for loading and intracellular delivery of antisense oligodeoxynucleotides [ASODNs], in which functionalized HNTs [f-HNTs] were used as carriers and ASODNs as a therapeutic gene for targeting survivin. HNTs were firstly surface-modified with γ-aminopropyltriethoxysilane in order to facilitate further biofunctionalization. The f-HNTs and the assembled f-HNT-ASODN complexes were characterized by transmission electron microscopy [TEM], dynamic light scattering, UV-visible spectroscopy, and fluorescence spectrophotometry. The intracellular uptake and delivery efficiency of the complexes were effectively investigated by TEM, confocal microscopy, and flow cytometry. In vitro cytotoxicity studies of the complexes using MTT assay exhibited a significant enhancement in the cytotoxic capability. The results exhibited that f-HNT complexes could efficiently improve intracellular delivery and enhance antitumor activity of ASODNs by the nanotube carrier and could be used as novel promising vectors for gene therapy applications, which is attributed to their advantages over structures and features including a unique tubular structure, large aspect ratio, natural availability, rich functionality, good biocompatibility, and high mechanical strength.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.