ArticleInternational journal of experimental pathology2011
Development of an acute model of inhalational melioidosis in the common marmoset (Callithrix jacchus).
Article in International journal of experimental pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Validation of a human-specific, multiplex platform for detecting common marmoset (Callithrix jacchus) inflammatory analytes.Cellular immunology · 2026Article
- Environmental Presence of Burkholderia pseudomallei at Military Sites in an Endemic Region: Implications for Future Deployments and Studies.The American journal of tropical medicine and hygiene · 2026Article
- Marmosets as models of infectious diseases.Frontiers in cellular and infection microbiology · 2024Review
- Melioidosis in Cynomolgus Macaques (Comparative medicine · 2022Article
- Efficacy of Co-Trimoxazole against Experimental Melioidosis Acquired by Different Routes of Infection.Antimicrobial agents and chemotherapy · 2022Article
- Histopathological and Immunological Findings in the Common Marmoset Following Exposure to Aerosolized SARS-CoV-2.Viruses · 2022Article
- The Innate Immune Response in the Marmoset during the Acute Pneumonic Disease Caused by Burkholderia pseudomallei.Infection and immunity · 2022Article
- Laboratory Safety: Handling Burkholderia pseudomallei Isolates without a Biosafety Cabinet.Journal of clinical microbiology · 2021Article
- The lymphatic system as a potential mechanism of spread of melioidosis following ingestion of Burkholderia pseudomallei.PLoS neglected tropical diseases · 2021Article
- Comparative virulence of three different strains of Burkholderia pseudomallei in an aerosol non-human primate model.PLoS neglected tropical diseases · 2021Article
- Dose-dependant acute or subacute disease caused by Burkholderia pseudomallei strain NCTC 13392 in a BALB/c aerosol model of infection.Journal of applied microbiology · 2019Article
- Novel multi-component vaccine approaches for Burkholderia pseudomallei.Clinical and experimental immunology · 2019Review
- Characterization of lesion formation in marmosets following inhalational challenge with different strains of Burkholderia pseudomallei.International journal of experimental pathology · 2015Article
- Article
- Comparative experimental subcutaneous glanders and melioidosis in the common marmoset (Callithrix jacchus).International journal of experimental pathology · 2014Article
- Pathogenesis of percutaneous infection of goats with Burkholderia pseudomallei: clinical, pathologic, and immunological responses in chronic melioidosis.International journal of experimental pathology · 2014Article
- Exploring the innate immunological response of an alternative nonhuman primate model of infectious disease; the common marmoset.Journal of immunology research · 2014Article
- Protection against experimental melioidosis following immunisation with a lipopolysaccharide-protein conjugate.Journal of immunology research · 2014Article
- Genome Sequence of Burkholderia pseudomallei NCTC 13392.Genome announcements · 2013Article
- Experimental respiratory Marburg virus haemorrhagic fever infection in the common marmoset (Callithrix jacchus).International journal of experimental pathology · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Studies of inhalational melioidosis were undertaken in the common marmoset (Callithrix jacchus). Following exposure to an inhaled challenge with aerosolized Burkholderia pseudomallei, lethal infection was observed in marmosets challenged with doses below 10 cfu; a precise LD(50) determination was not possible. The model was further characterized using a target challenge dose of approximately 10(2) cfu. A separate pathogenesis time-course experiment was also conducted. All animals succumbed, between 27 and 78 h postchallenge. The challenge dose received and the time to the humane endpoint (1 °C below normal body temperature postfever) were correlated. The first indicator of disease was an increased core body temperature (T(c) ), at 22 h postchallenge. This coincided with bacteraemia and bacterial dissemination. Overt clinical signs were first observed 3-5 h later. A sharp decrease (typically within 3-6 h) in the T(c) was observed prior to humanely culling the animals in the lethality study. Pathology was noted in the lung, liver and spleen. Disease progression in the common marmoset appears to be consistent with human infection in terms of bacterial spread, pathology and physiology. The common marmoset can therefore be considered a suitable animal model for further studies of inhalational melioidosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.