ArticleBehavioral neuroscience2011
Differential brain-derived neurotrophic factor expression in limbic brain regions following social defeat or territorial aggression.
Article in Behavioral neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Maternal separation increases anxiety-like phenotypes, fear responses, and altersNeurobiology of stress · 2026Article
- Changes in social, sexual, and hedonic behaviors in rats in response to stress and restoration by a negative allosteric modulator of α5-subunit containing GABA receptor.Behavioural brain research · 2023Article
- Neural systems that facilitate the representation of social rank.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Evolution of stress responses refine mechanisms of social rank.Neurobiology of stress · 2021Review
- Chemogenetic activation of an infralimbic cortex to basolateral amygdala projection promotes resistance to acute social defeat stress.Scientific reports · 2020Article
- The Relationships Between Stress, Mental Disorders, and Epigenetic Regulation of BDNF.International journal of molecular sciences · 2020Review
- Pharmacological modulation of the behavioral effects of social defeat in memory and learning in male mice.Psychopharmacology · 2019Article
- Complementary Neural Circuits for Divergent Effects of Oxytocin: Social Approach Versus Social Anxiety.Biological psychiatry · 2019Review
- Brain-derived neurotrophic factor signaling mitigates the impact of acute social stress.Neuropharmacology · 2019Article
- Interaction of basolateral amygdala, ventral hippocampus and medial prefrontal cortex regulates the consolidation and extinction of social fear.Behavioral and brain functions : BBF · 2018Article
- Dominance status alters restraint-induced neural activity in brain regions controlling stress vulnerability.Physiology & behavior · 2017Article
- RETRACTED: BNDF heterozygosity is associated with memory deficits and alterations in cortical and hippocampal EEG power.Behavioural brain research · 2017Article
- Exposure to extrinsic stressors, social defeat or bisphenol A, eliminates sex differences in DNA methyltransferase expression in the amygdala.Journal of neuroendocrinology · 2017Article
- Proteolytic cleavage of proBDNF into mature BDNF in the basolateral amygdala is necessary for defeat-induced social avoidance.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Social Plasticity Relies on Different Neuroplasticity Mechanisms across the Brain Social Decision-Making Network in Zebrafish.Frontiers in behavioral neuroscience · 2016Article
- Neurobiological mechanisms supporting experience-dependent resistance to social stress.Neuroscience · 2015Review
- A Social Network Approach Reveals Associations between Mouse Social Dominance and Brain Gene Expression.PloS one · 2015Article
- Maintenance of dominance status is necessary for resistance to social defeat stress in Syrian hamsters.Behavioural brain research · 2014Article
- Chronic social stress in puberty alters appetitive male sexual behavior and neural metabolic activity.Hormones and behavior · 2014Article
- 5-HT1A receptor activation reduces fear-related behavior following social defeat in Syrian hamsters.Pharmacology, biochemistry, and behavior · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Syrian hamsters readily form dominant-subordinate relationships under laboratory conditions. Winning or losing in agonistic encounters can have striking, long-term effects on social behavior, but the mechanisms underlying this experience-induced behavioral plasticity are unclear. The present study tested the hypothesis that changes in brain-derived neurotrophic factor (BDNF) may at least in part mediate this plasticity. Male hamsters were paired for 15-min using a resident-intruder model, and individuals were identified as winners or losers on the basis of their behavior. BDNF was examined with in situ hybridization 2 hr after treatment during the consolidation period of emotional learning. Losing animals had significantly more BDNF mRNA in the basolateral (BLA) and medial (MeA) nuclei of the amygdala when compared with winning animals as well as novel cage and home cage controls. Interestingly, winning animals had significantly more BDNF mRNA in the dentate gyrus of the dorsal hippocampus than did losing animals, novel, and home cage controls. No conflict-related changes in BDNF mRNA were observed in several other regions including the bed nucleus of the stria terminalis and central amygdala. Next, we demonstrated that K252a, a Trk receptor antagonist, significantly reduced the acquisition of conditioned defeat when administered within the BLA. These data support a model in which BDNF-mediated plasticity within the BLA supports learning of submission or subordinate social status in losing animals, whereas BDNF-mediated plasticity within the hippocampus may instantiate aspects of winning such as control of a territory in dominant animals.
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