ArticleBehavioral neuroscience2011
Reevaluating hippocampus-dependent learning in FVB/N mice.
Article in Behavioral neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- A bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifests 'space cadet syndrome' on two FVB backgrounds.Disease models & mechanisms · 2025Article
- Absence of hippocampal pathology persists in the Q175DN mouse model of Huntington's disease despite elevated HTT aggregation.Journal of Huntington's disease · 2025Article
- Longitudinal autophagy profiling of the mammalian brain reveals sustained mitophagy throughout healthy aging.The EMBO journal · 2024Article
- Mitophagy in the aging nervous system.Frontiers in cell and developmental biology · 2022Review
- Comment on "mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity thanAutophagy · 2021Article
- Kainate receptors regulate the functional properties of young adult-born dentate granule cells.Cell reports · 2021Article
- Notch3-Dependent Effects on Adult Neurogenesis and Hippocampus-Dependent Learning in a Modified Transgenic Model of CADASIL.Frontiers in aging neuroscience · 2021Article
- Article
- Impaired Hippocampal Synaptic Plasticity and Enhanced Excitatory Transmission in a Novel Animal Model of Autism Spectrum Disorders with Telomerase Reverse Transcriptase Overexpression.Molecules and cells · 2018Article
- Age-Dependent Cellular and Behavioral Deficits Induced by Molecularly Targeted Drugs Are Reversible.Cancer research · 2018Article
- ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis.Nature neuroscience · 2014Article
- Absence of strong strain effects in behavioral analyses of Shank3-deficient mice.Disease models & mechanisms · 2014Article
- Differences in memory development among C57BL/6NCrl, 129S2/SvPasCrl, and FVB/NCrl mice after delay and trace fear conditioning.Comparative medicine · 2014Article
- Learning increases intrinsic excitability of hippocampal interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The importance of considering all attributes of memory in behavioral endophenotyping of mouse models of genetic disease.Behavioral neuroscience · 2012Review
- Characterizing cognitive aging of associative memory in animal models.Frontiers in aging neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The FVB/N (FVB) mouse has been a popular background strain for constructing transgenic mice. However, behavioral phenotyping of the resultant mice is complicated, due to severe visual impairment in the FVB background strain. Previous studies reported cognitive impairments with the FVB strain, suggesting the background as unsuitable for behavioral analysis. In this study, we compared FVB mice to the well-characterized C57BL/6 (B6) strain in a battery of hippocampus-dependent tasks that had several nonvisual cues. The tasks included: trace eyeblink conditioning, spontaneous alternation in the Y maze, social recognition, trace and contextual fear conditioning, and odor habituation-dishabituation. FVB mice were able to learn all the tasks, often to similar levels as B6 mice. In contrast to previous reports, our data suggest FVB mice are not cognitively deficient with temporal memory tasks, when the tasks do not rely heavily upon vision. Thus, the FVB strain may be used as the genetic background for behavioral phenotyping when nonvisual hippocampal-dependent tasks are utilized.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.