ReviewEpigenomics2010
Transgenerational genetic effects.
Review in Epigenomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Epigenetic conditioning induces intergenerational resilience to dementia in a mouse model of vascular cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Plasticity to ocean warming is influenced by transgenerational, reproductive, and developmental exposure in a coral reef fish.Evolutionary applications · 2022Article
- Maternal Prepregnancy 5-Hydroxytryptamine Exposure Affects the Early Development of the Fetus.Frontiers in physiology · 2022Article
- Parental methyl-enhanced diet and in ovo corticosterone affect first generation Japanese quail (Coturnix japonica) development, behaviour and stress response.Scientific reports · 2021Article
- Paternal genetic variants and risk of obstructive heart defects: A parent-of-origin approach.PLoS genetics · 2021Article
- Ionizing Radiation-Induced Epigenetic Modifications and Their Relevance to Radiation Protection.International journal of molecular sciences · 2020Review
- Nutrition Transition and Cancer.Nutrients · 2020Review
- Genomic Variation, Evolvability, and the Paradox of Mental Illness.Frontiers in psychiatry · 2020Article
- Inter-generational resemblance of methylation levels at circadian genes and associations with phenology in the barn swallow.Scientific reports · 2019Article
- The model of "genetic compartments": a new insight into reproductive genetics.Journal of assisted reproduction and genetics · 2019Review
- The effect of birth weight on body composition: Evidence from a birth cohort and a Mendelian randomization study.PloS one · 2019Observational
- The Role of RNA Editing in Cancer Development and Metabolic Disorders.Frontiers in endocrinology · 2018Review
- Assessing the Heritability of Complex Traits in Humans: Methodological Challenges and Opportunities.Current genomics · 2017Review
- Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Social subordination stress and serotonin transporter polymorphisms: associations with brain white matter tract integrity and behavior in juvenile female macaques.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- Intergenerational programming of metabolic disease: evidence from human populations and experimental animal models.Cellular and molecular life sciences : CMLS · 2013Review
- Bridging the transgenerational gap with epigenetic memory.Trends in genetics : TIG · 2013Review
- Social and emotional predictors of the tempo of puberty in female rhesus monkeys.Psychoneuroendocrinology · 2013Article
- Mapping the genes for susceptibility and response to Leishmania tropica in mouse.PLoS neglected tropical diseases · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Since Mendel, studies of phenotypic variation and disease risk have emphasized associations between genotype and phenotype among affected individuals in families and populations. Although this paradigm has led to important insights into the molecular basis for many traits and diseases, most of the genetic variants that control the inheritance of these conditions continue to elude detection. Recent studies suggest an alternative mode of inheritance where genetic variants that are present in one generation affect phenotypes in subsequent generations, thereby decoupling the conventional relations between genotype and phenotype, and perhaps, contributing to 'missing heritability'. Under some conditions, these transgenerational genetic effects can be as frequent and strong as conventional inheritance, and can persist for multiple generations. Growing evidence suggests that RNA mediates these heritable epigenetic changes. The primary challenge now is to identify the molecular basis for these effects, characterize mechanisms and determine whether transgenerational genetic effects occur in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.