ArticleEpigenomics2010
Transgenerational genetic effects of the paternal Y chromosome on daughters' phenotypes.
Article in Epigenomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 61 citations in OpenAlex.
- Y and mitochondrial chromosomes in the heterogeneous stock rat population.G3 (Bethesda, Md.) · 2024Article
- Y and Mitochondrial Chromosomes in the Heterogeneous Stock Rat Population.bioRxiv : the preprint server for biology · 2023Article
- Parental sex-dependent effects of either maternal or paternal eNOS deficiency on the offspring's phenotype without transmission of the parental eNOS deficiency to the offspring.Frontiers in physiology · 2023Article
- Parental ecological history can differentially modulate parental age effects on offspring physiological traits inCurrent zoology · 2022Article
- Sex-limited chromosomes and non-reproductive traits.BMC biology · 2022Review
- Paternal eNOS deficiency in mice affects glucose homeostasis and liver glycogen in male offspring without inheritance of eNOS deficiency itself.Diabetologia · 2022Article
- A genome-wide test for paternal indirect genetic effects on lifespan inProceedings. Biological sciences · 2022Article
- Genetic control of non-genetic inheritance in mammals: state-of-the-art and perspectives.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Review
- Novel insights into the genetic background of genetically modified mice.Transgenic research · 2018Article
- Parental obesity leads to metabolic changes in the F2 generation inMolecular metabolism · 2017Article
- Large deletion on the Y-chromosome long arm (Yq) of C57BL/6JBomTac inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Stage dependent nutritional regulation of transgenerational longevity.Nutrition and healthy aging · 2016Article
- The XX Sex Chromosome Complement is Required in Male and Female Mice for Enhancement of Immunity Induced by Exposure to 3,4-Dichloropropionanilide.American journal of reproductive immunology (New York, N.Y. : 1989) · 2015Article
- Contrasting genetic architectures in different mouse reference populations used for studying complex traits.Genome research · 2015Review
- Number of X-chromosome genes influences social behavior and vasopressin gene expression in mice.Psychoneuroendocrinology · 2015Article
- Y genetic variation and phenotypic diversity in health and disease.Biology of sex differences · 2015Article
- Epigenetic inheritance of metabolic state.Current opinion in genetics & development · 2014Review
- CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits.BioData mining · 2014Article
- Intergenerational programming of metabolic disease: evidence from human populations and experimental animal models.Cellular and molecular life sciences : CMLS · 2013Review
- Epigenetic inheritance of disease and disease risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
aimsRecent evidence suggests that transgenerational genetic effects contribute to phenotypic variation in complex traits. To test for the general occurrence of these effects and to estimate their strength, we took advantage of chromosome substitution strains (CSSs) of mice where the Y chromosome of the host strain has been replaced with the Y chromosome of the donor strain. Daughters of these CSS-Y males and host strain females are genetically identical and should be phenotypically indistinguishable in the absence of transgenerational genetic effects of the fathers' Y chromosome on daughters' phenotypes. MATERIALS &
methodsAssay results for a broad panel of physiological traits and behaviors were compared for genetically identical daughters of CSS-Y males and host strain females from the B6-Chr(A/J) and B6-Chr(PWD) panels of CSSs. In addition, behavioral traits including specific tests for anxiety-related behaviors were tested in daughters of B6-Chr(129) and 129-Chr(B6) CSS-Y males.
resultsAcross a panel of 41 multigenic traits assayed in the B6-Chr(A/J) panel of CSSs females and 21 multigenic traits in the B6-Chr(PWD) panel females, the frequency and strength for transgenerational genetic effects were remarkably similar to those for conventional inheritance of substituted chromosomes. In addition, we found strong evidence that the Y chromosome from the 129 inbred strain significantly reduced anxiety levels among daughters of B6-Chr(129) CSS-Y males.
conclusionWe found that transgenerational genetic effects rival conventional genetic effects in frequency and strength, we suggest that some phenotypic variation found in conventional studies of complex traits are attributable in part to the action of genetic variants in previous generations, and we propose that transgenerational genetic effects contribute to 'missing heritability'.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.