ArticleTherapy (London, England : 2004)2011
Repositioning leptin as a therapy for Alzheimer's disease.
Article in Therapy (London, England : 2004), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- A Pathophysiological Intersection of Diabetes and Alzheimer's Disease.International journal of molecular sciences · 2022Review
- Nonobese Male Patients with Alzheimer's Disease Are Vulnerable to Decrease in Plasma Leptin.Journal of Alzheimer's disease : JAD · 2022Article
- Plasma Leptin Reflects Progression of Neurofibrillary Pathology in Animal Model of Tauopathy.Cellular and molecular neurobiology · 2022Article
- A multitude of signaling pathways associated with Alzheimer's disease and their roles in AD pathogenesis and therapy.Medicinal research reviews · 2021Review
- Insulin resistance, dyslipidemia, and apolipoprotein E interactions as mechanisms in cognitive impairment and Alzheimer's disease.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- The role of leptin in central nervous system diseases.Neuroreport · 2016Review
- Leptin applications in 2015: what have we learned about leptin and obesity?Current opinion in endocrinology, diabetes, and obesity · 2015Review
- Leptin upregulation in advanced multiple system atrophy with hypocholesterolemia and unexpected fat accumulation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Article
- Neuroprotective effects of leptin in the context of obesity and metabolic disorders.Neurobiology of disease · 2014Review
- Low plasma leptin in cognitively impaired ADNI subjects: gender differences and diagnostic and therapeutic potential.Current Alzheimer research · 2014Article
- The Cerebellum and Premenstrual Dysphoric Disorder.AIMS neuroscience · 2014Article
- Association between leptin and delirium in elderly inpatients.Neuropsychiatric disease and treatment · 2013Article
- The role of leptin in the control of insulin-glucose axis.Frontiers in neuroscience · 2013Article
- Alzheimer's disease and type 2 diabetes: exploring the association to obesity and tyrosine hydroxylase.CNS & neurological disorders drug targets · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The data from the initial clinical trials utilizing recombinant human leptin as an obesity therapy were published in 1998. Since then, numerous studies have been described which address dosage, safety and efficacy of leptin replacement for a variety of disorders with diverse patient groups, including pediatric and adult subjects. We review the current clinical trial data, demonstrate that leptin administration is safe for long term use in humans, and summarize reported cognitive benefits. The functions of leptin in neuroprotection and cognition have been largely overlooked. Accumulating data suggest a very significant application of leptin may be a therapy for Alzheimer's disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.