Evidence map›Paper›PMID 22120952›Full record

ArticleTransgenic research2012

Genetically modified crops and aquatic ecosystems: considerations for environmental risk assessment and non-target organism testing.

Keri Carstens, Jennifer Anderson, Pamela Bachman, Adinda De Schrijver, Galen Dively, Brian Federici, Mick Hamer, Marco Gielkens, Peter Jensen, William Lamp and 4 more

Abstract read
In one paragraph

Article in Transgenic research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Plant background, notFrontiers in plant science · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Genetically engineered eucalyptus expressing pesticidal proteins fromFrontiers in bioengineering and biotechnology · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Keri CarstensRegulatory Science, Pioneer Hi-Bred, DuPont Agricultural Biotechnology, 2450 SE Oak Tree Ct., Ankeny, IA 50021, USA. keri.carstens@pioneer.com
Jennifer Anderson
Pamela Bachman
Adinda De Schrijver
Galen Dively
Brian Federici
Mick Hamer
Marco Gielkens
Peter Jensen
William Lamp
Stefan Rauschen
Geoff Ridley
Jörg Romeis
Annabel Waggoner

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental risk assessments (ERA) support regulatory decisions for the commercial cultivation of genetically modified (GM) crops. The ERA for terrestrial agroecosystems is well-developed, whereas guidance for ERA of GM crops in aquatic ecosystems is not as well-defined. The purpose of this document is to demonstrate how comprehensive problem formulation can be used to develop a conceptual model and to identify potential exposure pathways, using Bacillus thuringiensis (Bt) maize as a case study. Within problem formulation, the insecticidal trait, the crop, the receiving environment, and protection goals were characterized, and a conceptual model was developed to identify routes through which aquatic organisms may be exposed to insecticidal proteins in maize tissue. Following a tiered approach for exposure assessment, worst-case exposures were estimated using standardized models, and factors mitigating exposure were described. Based on exposure estimates, shredders were identified as the functional group most likely to be exposed to insecticidal proteins. However, even using worst-case assumptions, the exposure of shredders to Bt maize was low and studies supporting the current risk assessments were deemed adequate. Determining if early tier toxicity studies are necessary to inform the risk assessment for a specific GM crop should be done on a case by case basis, and should be guided by thorough problem formulation and exposure assessment. The processes used to develop the Bt maize case study are intended to serve as a model for performing risk assessments on future traits and crops.

Indexed as

EnvironmentHydrobiologyRisk AssessmentAnimalsBacillus thuringiensisButterfliesHumansPlants, Genetically ModifiedResearch DesignZea mays

Identifiers

PMID22120952
PMCPMC3394238

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.