ArticleJournal of clinical pathology1990
Use of monoclonal antibody KP1 for identifying normal and neoplastic human mast cells.
Article in Journal of clinical pathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 55 citations in OpenAlex.
- Fussel-15, a new player in wound healing, is deregulated in keloid and localized scleroderma.The American journal of pathology · 2011Article
- Stem cell factor-dependent human cord blood derived mast cells express alpha- and beta-tryptase, heparin and chondroitin sulphate.Immunology · 1996Article
- Osteopontin expression and distribution in human carcinomas.The American journal of pathology · 1994Article
- A new monoclonal antibody (3A5) that recognises a fixative resistant epitope on tissue macrophages and monocytes.Journal of clinical pathology · 1994Article
- KP-1: not a specific marker. Staining of 137 sarcomas, 48 lymphomas, 28 carcinomas, 7 malignant melanomas and 8 cystosarcoma phyllodes.Virchows Archiv : an international journal of pathology · 1994Review
- PG-M1: a new monoclonal antibody directed against a fixative-resistant epitope on the macrophage-restricted form of the CD68 molecule.The American journal of pathology · 1993Article
- CD68 reactivity of non-macrophage derived tumours in cytological specimens.Journal of clinical pathology · 1993Article
- Association between mast cells and myelomonocytes.Journal of clinical pathology · 1992Article
- Ultrastructural localization of the CD68 macrophage-associated antigen in human blood neutrophils and monocytes.The American journal of pathology · 1991Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The monoclonal antibody KP1 (CD68) was used to stain normal and neoplastic monocytes and macrophages in routinely processed, paraffin wax embedded tissue: mast cells also exhibited strong, consistent cytoplasmic immunoreactivity. Light microscopic findings were corroborated by electron microscopical and immunocytochemical findings. The predominant sites of immunoreactivity were the specific intracytoplasmic granules of the mast cells. All mast cell subtypes--that is, normal and reactive mast cells, such as those in lymph nodes exhibiting chronic non-specific lymphadenitis, and malignant or neoplastic mast cells in various types of mastocytosis--reacted with this antibody. This finding is of diagnostic importance, because mast cell proliferation could be mistaken for histiocyte proliferation. It also supports the hypothesis that mast cells derive from the bone marrow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.