ArticleCellular signalling2012
A novel role for P2X7 receptor signalling in the survival of mouse embryonic stem cells.
Article in Cellular signalling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- P2X7 Receptors: An Untapped Target for the Management of Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- Neonatal Seizures and Purinergic Signalling.International journal of molecular sciences · 2020Review
- Comparative Embryonic Spatio-Temporal Expression Profile Map of theFrontiers in cellular neuroscience · 2019Article
- P2X7 Receptors Regulate Phagocytosis and Proliferation in Adult Hippocampal and SVZ Neural Progenitor Cells: Implications for Inflammation in Neurogenesis.Stem cells (Dayton, Ohio) · 2018Article
- De novo mutations in GRIN1 cause extensive bilateral polymicrogyria.Brain : a journal of neurology · 2018Article
- Molecular mechanisms of cardioprotective effects mediated by transplanted cardiac ckitOncotarget · 2018Article
- Neuronal P2X7 Receptor: Involvement in Neuronal Physiology and Pathology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Review
- Inflammasomes in Inflammation-Induced Cancer.Frontiers in immunology · 2017Review
- Tumor necrosis factor reduces Plasmodium falciparum growth and activates calcium signaling in human malaria parasites.Biochimica et biophysica acta · 2016Article
- P2X7 Receptor Inhibition Improves CD34 T-Cell Differentiation in HIV-Infected Immunological Nonresponders on c-ART.PLoS pathogens · 2016Article
- Valproic Acid Influences MTNR1A Intracellular Trafficking and Signaling in a β-Arrestin 2-Dependent Manner.Molecular neurobiology · 2016Article
- Purinergic signalling during development and ageing.Purinergic signalling · 2015Review
- Fluorescent dyes as a reliable tool in P2X7 receptor-associated pore studies.Journal of bioenergetics and biomembranes · 2015Article
- P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy.Cell research · 2015Article
- The role of purinergic receptors in stem cell differentiation.Computational and structural biotechnology journal · 2015Review
- The expression of P2X₇ receptors in EPCs and their potential role in the targeting of EPCs to brain gliomas.Cancer biology & therapy · 2015Article
- Modulation of mouse embryonic stem cell proliferation and neural differentiation by the P2X7 receptor.PloS one · 2014Article
- Purinergic signalling and cancer.Purinergic signalling · 2013Review
- Role of the P2X7 receptor in the osteogenic differentiation of mesenchymal cells and in osteoclast fusion : presented by: Maria P. Abbracchio.Purinergic signalling · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The growth of a pluripotent embryonic stem (ES) cell population is dependent on cell survival, proliferation and self-renewal. The nucleotide ATP represents an important extracellular signalling molecule that regulates the survival of differentiated cells, however, its role is largely undefined in embryonic stem cells. Here we report a role for ATP-gated P2X7 receptors in ES cell survival. The functional expression of P2X7 receptors in undifferentiated mouse ES cells is demonstrated using a selective P2X7 antagonist and small interfering RNA knockdown of these receptors. Our data illustrate a key role for the P2X7 receptor as an essential pro-survival signal required for optimal ES cell colony growth in the presence of leukemia inhibitor factor (LIF). However, chronic exposure to exogenous ATP leads to rapid P2X7-dependent cell death via necrosis. Together, these data demonstrate a novel role for P2X7 receptors in regulation of ES cell behaviour where they can mediate either a pro-survival or pro-death signal depending on the mode of activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.