ArticleInternational journal of cancer2012
Estimated phytanic acid intake and prostate cancer risk: a prospective cohort study.
Article in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies.European journal of epidemiology · 2021Pooled it
- A review and meta-analysis of prospective studies of red and processed meat, meat cooking methods, heme iron, heterocyclic amines and prostate cancer.Nutrition journal · 2015Pooled it
- Dietary factors and risk for advanced prostate cancer.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2014Pooled it
- Calcium Activation of the Androgen Receptor in Prostate Cells.International journal of endocrinology · 2023Article
- Phytanic acid, an inconclusive phytol metabolite: A review.Current research in toxicology · 2023Article
- Fish consumption and risk of prostate cancer or its mortality: an updated systematic review and dose-response meta-analysis of prospective cohort studies.Frontiers in nutrition · 2023Review
- Metabolomic analysis of serum alpha-tocopherol among men in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study.European journal of clinical nutrition · 2022Article
- Phytol and its metabolites phytanic and pristanic acids for risk of cancer: current evidence and future directions.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2020Review
- Intake of individual fatty acids and risk of prostate cancer in the European prospective investigation into cancer and nutrition.International journal of cancer · 2020Article
- Do dietary calcium and vitamin D matter in men with prostate cancer?Nature reviews. Urology · 2018Review
- Metabolomics-A Promising Approach to Pituitary Adenomas.Frontiers in endocrinology · 2018Review
- Calcium intake, polymorphisms of the calcium-sensing receptor, and recurrent/aggressive prostate cancer.Cancer causes & control : CCC · 2015Article
- Serum phytanic and pristanic acid levels and prostate cancer risk in Finnish smokers.Cancer medicine · 2014Article
- Prostate cancer and the influence of dietary factors and supplements: a systematic review.Nutrition & metabolism · 2014Review
- The role of an abnormal prostate-specific antigen level and an abnormal digital rectal examination in the diagnosis of prostate cancer: A cross-sectional study in Qatar.Arab journal of urology · 2013Article
- Phytanic acid and the risk of non-Hodgkin lymphoma.Carcinogenesis · 2013Article
- [Prevention of uro-oncological diseases].Der Urologe. Ausg. A · 2012Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Phytanic acid is a saturated fatty acid found predominantly in red meat and dairy products and may contribute to increases in prostate cancer risk that are observed with higher intakes of these foods. We constructed a novel summary measure of phytanic acid intake and prospectively examined its association with prostate cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study--a cohort of Finnish male smokers aged 50-69 years. Diet was assessed at baseline in 27,111 participants using a validated 276-item dietary questionnaire. Since phytanic acid is not currently included in food composition tables, we used the published phytanic acid content of 151 major food items to estimate total daily intake. During up to 21 years of follow-up, a total of 1,929 incident prostate cancer cases (including 438 advanced cases) were identified. Higher phytanic acid intake, though unrelated to the risk of localized disease [relative risks (RR) and 95% confidence intervals (CI) for increasing quartiles of intake = 1.00 (ref), 0.83 (0.68-1.01), 0.76 (0.62-0.94) and 0.91 (0.74-1.13); p trend = 0.23], was associated with increased risks of advanced prostate cancer [RR and 95% CI = 1.00 (ref), 1.43 (1.09-1.89), 1.31 (0.99-1.75) and 1.38 (1.02-1.89); p trend = 0.06]. This association appeared to be driven predominantly by phytanic acid obtained from dairy products (particularly butter). Our study indicates that phytanic acid may contribute to previously observed associations between high-fat animal foods (particularly dairy products) and prostate cancer risk, although some caution is warranted as it may be acting as a surrogate marker of dairy fat.
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