ArticleNature methods2011
Decoding cell lineage from acquired mutations using arbitrary deep sequencing.
Article in Nature methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Bayesian Phylogenetic Lineage Reconstruction with Loss of Heterozygosity Mutations Derived from Single-Cell RNA Sequencing.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Startle: A star homoplasy approach for CRISPR-Cas9 lineage tracing.Cell systems · 2023Article
- Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped cortical development.Cell systems · 2022Article
- Accounting for cell type hierarchy in evaluating single cell RNA-seq clustering.Genome biology · 2020Article
- Sample path properties of the average generation of a Bellman-Harris process.Journal of mathematical biology · 2019Article
- Recording development with single cell dynamic lineage tracing.Development (Cambridge, England) · 2019Review
- The use of technical replication for detection of low-level somatic mutations in next-generation sequencing.Nature communications · 2019Article
- Molecular diagnosis of PIK3CA-related overgrowth spectrum (PROS) in 162 patients and recommendations for genetic testing.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Article
- A generic, cost-effective, and scalable cell lineage analysis platform.Genome research · 2016Article
- UbC-StarTrack, a clonal method to target the entire progeny of individual progenitors.Scientific reports · 2016Article
- Inferring average generation via division-linked labeling.Journal of mathematical biology · 2016Article
- Whole-organism lineage tracing by combinatorial and cumulative genome editing.Science (New York, N.Y.) · 2016Article
- Ultra-precise detection of mutations by droplet-based amplification of circularized DNA.BMC genomics · 2016Article
- A metabolic perspective of Peto's paradox and cancer.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- The renaissance of developmental biology.PLoS biology · 2015Article
- Cancer evolution: mathematical models and computational inference.Systematic biology · 2015Review
- Barrett oesophagus: lessons on its origins from the lesion itself.Nature reviews. Gastroenterology & hepatology · 2015Review
- Detecting ultralow-frequency mutations by Duplex Sequencing.Nature protocols · 2014Article
- Genome sequencing of normal cells reveals developmental lineages and mutational processes.Nature · 2014Article
- Enhancing the detection of barcoded reads in high throughput DNA sequencing data by controlling the false discovery rate.BMC bioinformatics · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Because mutations are inevitable, the genome of each cell in a multicellular organism becomes unique and therefore encodes a record of its ancestry. Here we coupled arbitrary single primer PCR with next-generation DNA sequencing to catalog mutations and deconvolve the phylogeny of cultured mouse cells. This study helps pave the way toward construction of retrospective cell-fate maps based on mutations accumulating in genomes of somatic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.