ArticleRheumatology (Oxford, England)2012
Modifiable risk factors for RA: prevention, better than cure?
Article in Rheumatology (Oxford, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Evidence-based core information for health communication of tobacco control: The effect of smoking on risks of female disease.Frontiers in public health · 2022Pooled it
- Adiposity and the risk of rheumatoid arthritis: a systematic review and meta-analysis of cohort studies.Scientific reports · 2020Pooled it
- Coffee or tea consumption and the risk of rheumatoid arthritis: a meta-analysis.Clinical rheumatology · 2014Pooled it
- Effectiveness of a Web-Based Personalized Rheumatoid Arthritis Risk Tool With or Without a Health Educator for Knowledge of Rheumatoid Arthritis Risk Factors.Arthritis care & research · 2018Trial
- Personalized Risk Estimator for Rheumatoid Arthritis (PRE-RA) Family Study: rationale and design for a randomized controlled trial evaluating rheumatoid arthritis risk education to first-degree relatives.Contemporary clinical trials · 2014Trial
- Cigarette smoking habits and attitudes among rheumatoid arthritis patients at a tertiary centre in South Africa.Journal of the colleges of medicine of South Africa · 2026Article
- Development and internal validation of a prediction model for rheumatoid arthritis: a case-control study.Scientific reports · 2025Article
- The role of triglycerides in predicting new-onset arthritis in the general population over 45 years old: evidence from the China health and retirement longitudinal study.Frontiers in endocrinology · 2025Article
- Article
- Does the Change of Weather Influence Disease Activity in Rheumatoid Arthritis Patients: Patients' Self-Assessment via WebApp.Journal of clinical medicine · 2024Article
- Disease Activity, Inflammation Markers, and Quality of Life Are Associated with Muscle Strength in Croatian Rheumatoid Arthritis Patients-A National-Based Study.Medicina (Kaunas, Lithuania) · 2024Article
- Nano-platform Strategies of Herbal Components for the Management of Rheumatoid Arthritis: A Review on the Battle for Next-Generation Formulations.Current drug delivery · 2024Review
- Association between Nutritional Status, Lifestyle Habits, and Disease Activity in Dalmatian Patients with Rheumatoid Arthritis.Nutrients · 2023Article
- A stronger association of depression with rheumatoid arthritis in presence of obesity and hypertriglyceridemia.Frontiers in epidemiology · 2023Article
- Worse outcomes linked to ethnicity for early inflammatory arthritis in England and Wales: a national cohort study.Rheumatology (Oxford, England) · 2022Observational
- The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications.The Biochemical journal · 2022Review
- Neither low social support nor low decision latitude at work is associated with disease remission among patients with rheumatoid arthritis: results from the Swedish EIRA study.Arthritis research & therapy · 2022Article
- Pharmacological evaluation of anti-arthritic potential of terpinen-4-ol using in vitro and in vivo assays.Inflammopharmacology · 2022Article
- The burden of low back pain, rheumatoid arthritis, osteoarthritis, and gout and their respective attributable risk factors in Brazil: results of the GBD 2017 study.Revista da Sociedade Brasileira de Medicina Tropical · 2022Article
- Assessing improved risk prediction of rheumatoid arthritis by environmental, genetic, and metabolomic factors.Seminars in arthritis and rheumatism · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveTo perform a meta-synthesis of the evidence for modifiable lifestyle risk factors for inflammatory polyarthritis (IP) and RA.
methodsWe performed a MEDLINE literature search. Case-control and cohort studies and systematic reviews published from 1948 through February 2011 and studying modifiable risk factors for RA were retrieved. The main outcome measure was diagnosis of RA according to the standard criteria.
resultsSmoking contributes up to 25% of the population burden of RA. The risk is dose related, stronger in males and especially strong for anti-citrullinated peptide antibody positive (ACPA(+)) RA through an interaction with the shared epitope. After smoking cessation, there is, however, a latency of up to 20 years to return to baseline risk. Other associations are less definitive; however, prospective studies suggest that dietary antioxidants and breastfeeding may be protective and that high coffee consumption may increase RA risk. An inverse association with alcohol intake (especially in smokers) and with education/social class (especially seropositive RA) and an increased risk with obesity (seronegative RA) is also noted.
conclusionThere is a need for further large-scale prospective studies with a consistent definition of RA phenotype (undifferentiated IP through to ACPA(+)/RF(+) disease). This will ultimately afford the opportunity to evaluate preventative population strategies for RA akin to the well-established programmes for cardiovascular disease and cancer, targeting common risk factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.