ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2012
Activation pattern of neutrophils from blood of elderly individuals with Candida-related denture stomatitis.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Host's Immunity andMicroorganisms · 2022Review
- Neutrophil dynamics and inflammaging in acute ischemic stroke: A transcriptomic review.Frontiers in aging neuroscience · 2022Review
- Fcγ receptors on aging neutrophils.Journal of applied oral science : revista FOB · 2021Article
- Neutrophil-derived chemokines on the road to immunity.Seminars in immunology · 2016Review
- Nucleosides present on phlebotomine saliva induce immunossuppression and promote the infection establishment.PLoS neglected tropical diseases · 2015Article
- Proinflammatory profile of in vitro monocytes in the ageing is affected by lymphocytes presence.Immunity & ageing : I & A · 2013Article
- Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity.Open biology · 2012Review
- Relationship between removable prosthesis and some systemics disorders.Journal of Indian Prosthodontic SocietyReview
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified impaired neutrophils in elderly individuals which could be involved with Candida-related denture stomatitis (DS), an oral infection predominantly caused by Candida albicans, affecting especially elderly individuals using dental prosthesis. However, specific mechanisms performed by neutrophil contributing to the susceptibility of the elderly to DS are not fully understood. This study evaluated activation features of blood neutrophils from elderly and young individuals with DS. Blood neutrophils cultured with C. albicans from elderly subjects secreted decreased levels of CXCL8. However, C. albicans challenged-neutrophils from DS patients produced high IL-4 and IL-10, and low GM-CSF levels, regardless of age. Additional elastase activity of neutrophils from both elderly groups was detected after incubation with C. albicans, but only neutrophils from elderly DS demonstrated high myeloperoxidase activity. Therefore, DS patients have affected neutrophils, and the advance of age intensifies these damages. In summary, individuals with Candida-related denture stomatitis presented variation in the neutrophil phenotype and activation. Such alterations were more intense in neutrophils from infected elderly individuals.
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