ReviewExperimental brain research2012
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin.
Review in Experimental brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Article
- Review
- Melatonin Attenuates Methamphetamine-Induced Alteration of Amyloid β Precursor Protein Cleaving Enzyme Expressions via Melatonin Receptor in Human Neuroblastoma Cells.Neurotoxicity research · 2022Article
- Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption.CNS neuroscience & therapeutics · 2020Article
- Deep cervical lymph node ligation aggravates AD-like pathology of APP/PS1 mice.Brain pathology (Zurich, Switzerland) · 2019Article
- TheFrontiers in neuroscience · 2019Article
- Calcium-Sensing Receptor Antagonist NPS 2143 Restores Amyloid Precursor Protein Physiological Non-Amyloidogenic Processing in Aβ-Exposed Adult Human Astrocytes.Scientific reports · 2017Article
- The Neuroprotective Properties of the Amyloid Precursor Protein Following Traumatic Brain Injury.Aging and disease · 2016Review
- The keystone of Alzheimer pathogenesis might be sought in Aβ physiology.Neuroscience · 2015Review
- Activity dependent CAM cleavage and neurotransmission.Frontiers in cellular neuroscience · 2015Review
- Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression.Acta neuropathologica communications · 2014Article
- Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer's Disease.Current neuropharmacology · 2014Article
- The role of proteases in regulating Eph/ephrin signaling.Cell adhesion & migration · 2014Review
- PMEL: a pigment cell-specific model for functional amyloid formation.Pigment cell & melanoma research · 2013Review
- Interplay between α-, β-, and γ-secretases determines biphasic amyloid-β protein level in the presence of a γ-secretase inhibitor.The Journal of biological chemistry · 2013Article
- Tailoring of membrane proteins by alternative splicing of pre-mRNA.Biochemistry · 2012Review
- The physiological functions of the β-amyloid precursor protein APP.Experimental brain research · 2012Article
- The amyloid precursor protein forms plasmalemmal clusters via its pathogenic amyloid-β domain.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease causing mutations in the amyloid precursor protein (APP) or in the Presenilin 1 (PS1) or Presenilin 2 (PS2) genes increase the production of amyloid peptides (Aβ) that precipitate in amyloid plaques. Since amyloid plaques are also a prominent feature of sporadic Alzheimer's disease (AD), abnormal proteolysis of APP and the generation of amyloid beta (Aβ) are key events in the pathogenesis of AD. The proteases (secretases) that cleave APP are therefore important therapeutic targets, both for the rare familial forms but likely also for the sporadic forms of AD. The identification and understanding of the (neuro)biological functions of the α-, β-, and presenilin/γ-secretase (complexes) is important for the development of drugs and the delineation of their associated side effects. The potential impact of this type of research exceeds the AD field since the function of these secretases are also linked to cellular pathways like ectodomain shedding of growth factors and regulated intramembrane proteolysis of receptors in developmental biology, tissue homeostasis, and tumorigenesis. The generation of mice deficient in presenilin 1, presenilin 2, the α-secretase ADAM10, and the β-secretases BACE1 and BACE2 were instrumental for the elucidation of the physiological functions of these proteases. Using these mouse models understanding how these secretases regulate amyloid peptide formation and how they exert their diverse biological functions could be significantly increased. This review attempts to summarize selected aspects of the current view of the multiple roles such proteases play in health and disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.