ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2012
IRF-2 is over-expressed in pancreatic cancer and promotes the growth of pancreatic cancer cells.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 36 citations in OpenAlex.
- A randomized clinical trial of nerve block to manage end-stage pancreatic cancerous pain.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Trial
- The multiple roles of interferon regulatory factor family in health and disease.Signal transduction and targeted therapy · 2024Review
- IRF2 loss is associated with reduced MHC I pathway transcripts in subsets of most human cancers and causes resistance to checkpoint immunotherapy in human and mouse melanomas.Journal of experimental & clinical cancer research : CR · 2024Article
- IRF2 loss is associated with reduced MHC I pathway transcripts in subsets of most human cancers and causes resistance to checkpoint immunotherapy in human and mouse melanomas.Research square · 2024Article
- Investigation of cell cytotoxic activity and molecular mechanism of 5β,19-epoxycucurbita-6,23(Pharmaceutical biology · 2022Article
- Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer.BMC genomic data · 2022Article
- IRF2-induced Claudin-7 suppresses cell proliferation, invasion and migration of oral squamous cell carcinoma.Experimental and therapeutic medicine · 2022Article
- A Novel Pyroptosis-Associated Gene Signature to Predict Prognosis in Patients with Colorectal Cancer.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Dual role of ARPC1B in regulating the network between tumor-associated macrophages and tumor cells in glioblastoma.Oncoimmunology · 2022Article
- Genome-wide characterization of copy number variations in the host genome in genetic resistance to Marek's disease using next generation sequencing.BMC genetics · 2020Article
- IRF-2 Inhibits Gastric Cancer Invasion and Migration by Down-Regulating MMP-1.Digestive diseases and sciences · 2020Article
- Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3.Journal for immunotherapy of cancer · 2019Article
- Insights into the Mutational Burden of Human Induced Pluripotent Stem Cells from an Integrative Multi-Omics Approach.Cell reports · 2018Article
- Interferon regulatory factor 1 inactivation in human cancer.Bioscience reports · 2018Review
- Prognostic value of IRF-2 expression in colorectal cancer.Oncotarget · 2017Article
- MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer.Cell death & disease · 2017Article
- A network-pathway based module identification for predicting the prognosis of ovarian cancer patients.Journal of ovarian research · 2016Article
- 13-acetoxysarcocrassolide induces apoptosis on human gastric carcinoma cells through mitochondria-related apoptotic pathways: p38/JNK activation and PI3K/AKT suppression.Marine drugs · 2014Article
- Induction of apoptosis by sinulariolide from soft coral through mitochondrial-related and p38MAPK pathways on human bladder carcinoma cells.Marine drugs · 2012Article
- The IRF family of transcription factors: Inception, impact and implications in oncogenesis.Oncoimmunology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatic cancer is one of the most malignant diseases in the world. Interferon regulator factor 2 (IRF-2), an interferon regulatory factor, has been known to act as an oncogene in distinct types of cancer. In this study, we found that the expression of IRF-2 was up-regulated in primary pancreatic cancer samples and associated with tumor size, differentiation, tumor-node-metastasis stage, and survival of the patients. In pancreatic cancer cells, knockdown on the expression of IRF-2 inhibited cell growth in the liquid culture and on the soft agar. Mechanistically, IRF-2 modulated the growth of pancreatic cancer cells through regulating proliferation and apoptosis effectors, such as cyclin D1 and BAX. Collectively, these results suggest that IRF-2 plays an important role in the tumorigenesis of pancreatic cancer and down-regulation of IRF-2 would be a new treatment target for pancreatic cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.