ReviewBehavioural processes2012
Disentangling the nature of the nicotine stimulus.
Review in Behavioural processes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- The inside story: Interoceptive Pavlovian conditioning with the nicotine stimulus.Journal of experimental psychology. Animal learning and cognition · 2025Review
- Use of the overexpectation effect to reduce conditioned seeking behavior controlled by nicotine.Psychonomic bulletin & review · 2024Article
- Appetitive Pavlovian conditioning of the stimulus effects of nicotine enhances later nicotine self-administration.Journal of the experimental analysis of behavior · 2022Article
- Inactivation of posterior but not anterior dorsomedial caudate-putamen impedes learning with self-administered nicotine stimulus in male rats.Behavioural brain research · 2021Article
- Conditioned enhancement of the nicotine reinforcer.Experimental and clinical psychopharmacology · 2021Article
- Varenicline rescues nicotine-induced decrease in motivation for sucrose reinforcement.Behavioural brain research · 2021Article
- The importance of acquisition learning on nicotine and varenicline drug substitution in a drug-discriminated goal-tracking task.Pharmacology, biochemistry, and behavior · 2020Article
- Assessment of individual differences in response to acute bupropion or varenicline treatment using a long-access nicotine self-administration model and behavioral economics in female rats.Behavioural brain research · 2020Article
- Exploring the interoceptive stimulus effects of nicotine and varenicline.Pharmacology, biochemistry, and behavior · 2019Article
- Individual differences in responding to bupropion or varenicline in a preclinical model of nicotine self-administration vary according to individual demand for nicotine.Neuropharmacology · 2019Article
- Nicotine- and cocaine-triggered methamphetamine reinstatement in female and male Sprague-Dawley rats.Pharmacology, biochemistry, and behavior · 2017Article
- The effect of switching pharmacological intervention during extinction on nicotine-evoked conditioned responding in rats.Psychopharmacology · 2015Article
- Interoceptive conditioning with nicotine using extinction and re-extinction to assess stimulus similarity with bupropion.Neuropharmacology · 2014Article
- Critical role of peripheral sensory systems in mediating the neural effects of nicotine following its acute and repeated exposure.Reviews in the neurosciences · 2014Review
- Iptakalim attenuates self-administration and acquired goal-tracking behavior controlled by nicotine.Neuropharmacology · 2013Article
- Interoceptive conditioning in rats: effects of using a single training dose or a set of 5 different doses of nicotine.Pharmacology, biochemistry, and behavior · 2013Article
- Rapid sensitization of physiological, neuronal, and locomotor effects of nicotine: critical role of peripheral drug actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Interoceptive conditioning with a nicotine stimulus is susceptible to reinforcer devaluation.Behavioral neuroscience · 2013Article
- Are tobacco dependence and withdrawal related amongst heavy smokers? Relevance to conceptualizations of dependence.Journal of abnormal psychology · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Learning involving interoceptive stimuli likely plays an important role in many diseases and psychopathologies. Within this area, there has been extensive research investigating the interoceptive stimulus effects of abused drugs. In this pursuit, behavioral pharmacologists have taken advantage of what is known about learning processes and adapted the techniques to investigate the behavioral and receptor mechanisms of drug stimuli. Of particular interest is the nicotine stimulus and the use of the two-lever operant drug discrimination task and the Pavlovian drug discriminated goal-tracking task. There is strong concordance between the two methods when using "standard" testing protocols that minimize learning on test days. For example, ABT-418, nornicotine, and varenicline all fully evoked nicotine-appropriate responding. Notably, research from our laboratory with the discriminated goal-tracking task has used an alternative testing protocol. This protocol assesses stimulus substitution based on how well extinction learning using a non-nicotine ligand transfers back to the nicotine stimulus. These findings challenge conclusions based on more "standard" testing procedures (e.g., ABT-418 is not nicotine-like). As a starting point, we propose Thurstone scaling as a quantitative method for more precisely comparing transfer of extinction across doses, experiments, and investigators. We close with a discussion of future research directions and potential implications of the research for understanding interoceptive stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.