ArticleMitochondrion2012
Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy.
Article in Mitochondrion, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Adaptation of OXPHOS biogenesis to cellular requirements.Protein science : a publication of the Protein Society · 2026Review
- Integrative Proteomic and Bioenergetic Profiling Reveals Diet- and Strain-Specific Mitochondrial Dysfunction in Cohen Diabetic Rat Hearts.Antioxidants (Basel, Switzerland) · 2026Article
- Mitochondrial proteins contribute to the pathogenesis of myasthenia gravis.Scientific reports · 2025Article
- Dissecting regulatory non-coding GWAS loci reveals fibroblast causal genes with pathophysiological relevance to heart failure.Nature communications · 2025Article
- Supercomplex Restructuring in Heart Mitochondria of COX7A1-Deficient Mice.Biomolecules · 2025Article
- Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity.Immunity · 2025Article
- Enhancing Osteogenesis through Bio-Inspired Recombinant Coral Protein Galaxin by Targeting Mitochondrial Metabolism and ATP Production.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Knockout mouse models as a resource for the study of rare diseases.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Article
- An X-linkedTranslational pediatrics · 2022Article
- Concordant and Heterogeneity of Single-Cell Transcriptome in Cardiac Development of Human and Mouse.Frontiers in genetics · 2022Article
- Loss of COX4I1 Leads to Combined Respiratory Chain Deficiency and Impaired Mitochondrial Protein Synthesis.Cells · 2021Article
- Free Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice.Frontiers in immunology · 2021Article
- Role of cytochrome c oxidase nuclear-encoded subunits in health and disease.Physiological research · 2020Review
- COX7A1 suppresses the viability of human non-small cell lung cancer cells via regulating autophagy.Cancer medicine · 2019Article
- Myocardial insufficiency is related to reduced subunit 4 content of cytochrome c oxidase.Journal of cardiothoracic surgery · 2018Article
- Aerobic Exercise Preconception and During Pregnancy Enhances Oxidative Capacity in the Hindlimb Muscles of Mice Offspring.Journal of strength and conditioning research · 2018Article
- Use of deep neural network ensembles to identify embryonic-fetal transition markers: repression ofOncotarget · 2018Article
- Adipose tissues of MPC1PeerJ · 2018Article
- Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain.Nature structural & molecular biology · 2017Review
- Increased Hemodynamic Load in Early Embryonic Stages Alters Myofibril and Mitochondrial Organization in the Myocardium.Frontiers in physiology · 2017Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Subunit 7a of mouse cytochrome c oxidase (Cox) displays a contractile muscle-specific isoform, Cox7a1, that is the major cardiac form. To gain insight into the role of this isoform, we have produced a new knockout mouse line that lacks Cox7a1. We show that homozygous and heterozygous Cox7a1 knockout mice, although viable, have reduced Cox activity and develop a dilated cardiomyopathy at 6 weeks of age. Surprisingly, the cardiomyopathy improves and stabilizes by 6 months of age. Cox7a1 knockout mice incorporate more of the "liver-type" isoform Cox7a2 into the cardiac Cox holoenzyme and, also surprisingly, have higher tissue ATP levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.