Evidence map›Paper›PMID 22119749›Full record

ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2012

Adaptive evolution and fixation of drug-resistant Plasmodium falciparum genotypes in pregnancy-associated malaria: 9-year results from the QuEERPAM study.

Steve M Taylor, Alejandro Antonia, Gaoqian Feng, Victor Mwapasa, Ebbie Chaluluka, Malcolm Molyneux, Feiko O ter Kuile, Stephen J Rogerson, Steven R Meshnick

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In one paragraph

Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 5 countries.

Steve M TaylorDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA. taylo115@email.unc.edu
Alejandro Antonia
Gaoqian Feng
Victor Mwapasa
Ebbie Chaluluka
Malcolm Molyneux
Feiko O ter Kuile
Stephen J Rogerson
Steven R Meshnick
Malawi-Liverpool-Wellcome Trust Clinical Research Programme · MWUniversity of Melbourne · AUUniversity of North Carolina at Chapel Hill · USDuke Medical Center · USLiverpool School of Tropical Medicine · GBUniversity of Liverpool · GB

Funding

MALARIA AND HIV IN PREGNANT WOMEN IN MALAWIR01AI049084 · NIAID · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI MESHNICK, STEVEN RICHARD · 2001 to 2005
$1.5M
TRAINING MED SCHOOL FACULTY TO TACKLE MALARIA IN MALAWID43TW000908 · FIC · MICHIGAN STATE UNIVERSITY · PI TAYLOR, TERRIE ELLEN · 1997 to 2002
$430k
FIC NIH HHS 5 D43 TW00908FIC NIH HHS D43 TW000908NIAID NIH HHS AI 49084NIAID NIH HHS R01 AI049084Wellcome Trust
6 · The paper itself

Abstract

Sulfadoxine-pyrimethamine (SP) has been widely deployed in Africa for malaria control and molecular evidence of parasite drug-resistance is prevalent. However, the temporal effects on the selection of Plasmodium falciparum are not well understood. We conducted a retrospective serial cross-sectional study between 1997 and 2006 to investigate changes in drug-resistant malaria among pregnant women delivering at a single hospital in Blantyre, Malawi. P. falciparum parasites were genotyped for parasite clone multiplicity and drug-resistance mutations, and the strength of selection upon mutant genotypes was quantified. Five mutations in the dihydrofolate reductase and dihydropteroate synthase genes began at moderate frequencies and achieved fixation by 2005; the frequency of the highly-SP-resistant "quintuple mutant" haplotype increased from 19% to 100%. The selective advantage of alleles and haplotypes were quantified with selection coefficients: Selection was positive on all mutant alleles and haplotypes associated with SP resistance, and the relative fitness of the quintuple mutant haplotype was 0.139 (95% C.I. 0.067-0.211), indicating a substantial positive selective advantage. Mutations that confer higher levels of resistance to SP did not emerge. SP-resistant haplotypes were rapidly selected for and fixed in P. falciparum populations infecting pregnant women while SP was widely deployed in Malawi. These results underscore the pressing need for new preventive measures for pregnancy-associated malaria and provide a real-world model of the selection landscape malaria parasites.

Indexed as

Evolution, MolecularGenotypeAdaptation, BiologicalAdolescentAdultCross-Sectional StudiesDihydropteroate SynthaseDrug ResistanceFemaleGene FrequencyHumansMalaria, FalciparumMalawiMutationPlasmodium falciparumPregnancyDihydropteroate SynthaseTetrahydrofolate Dehydrogenase

Identifiers

PMID22119749
PMCPMC3293939
OpenAlexW2108649094

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.