ReviewSocial science & medicine (1982)2012
How does the social environment 'get into the mind'? Epigenetics at the intersection of social and psychiatric epidemiology.
Review in Social science & medicine (1982), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 223 citations in OpenAlex.
- Understanding the genetics and epigenetics of bulimia nervosa/bulimia spectrum disorder and comorbid borderline personality disorder (BN/BSD-BPD): a systematic review.Eating and weight disorders : EWD · 2019Pooled it
- Biological and psychosocial predictors of postpartum depression: systematic review and call for integration.Annual review of clinical psychology · 2015Pooled it
- Pooled it
- Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women.Translational psychiatry · 2016Trial
- Article
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- Development of a harmonized sociodemographic and clinical questionnaire for mental health research: A Delphi-method-based consensus recommendation.The Australian and New Zealand journal of psychiatry · 2024Review
- TNFα Induces DNA and Histone Hypomethylation and Pulmonary Artery Smooth Muscle Cell Proliferation Partly via Excessive Superoxide Formation.Antioxidants (Basel, Switzerland) · 2024Article
- Temperament impact on eating disorder symptoms and habit formation: a novel model to inform treatment.Journal of eating disorders · 2024Review
- I Don't Want to Be Thin! Fear of Weight Change Is Not Just a Fear of Obesity: Research on the Body Mass Anxiety Scale.International journal of environmental research and public health · 2023Article
- Review
- Psychosocial experiences modulate asthma-associated genes through gene-environment interactions.eLife · 2021Article
- Epigenome-Wide Study of Posttraumatic Stress Disorder Symptom Severity in a Treatment-Seeking Adolescent Sample.Journal of traumatic stress · 2021Article
- Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood.Clinical epigenetics · 2021Article
- The Role of Social Determinants in Mental Health and Resilience After Disasters: Implications for Public Health Policy and Practice.Frontiers in public health · 2021Review
- ADVERSITY, MENTAL HEALTH, AND SUBSTANCE USE DISORDERS AS PREDICTORS AND MEDIATORS OF RULE VIOLATIONS IN U.S. PRISONS.Criminal justice and behavior · 2020Article
- Epigenetics recording varied environment and complex cell events represents the origin of cellular aging.Journal of Zhejiang University. Science. B · 2019Review
- Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders.Molecular psychiatry · 2019Review
- Genetics of language and its implications on language interventions.Journal of genetics · 2018Review
- Associations between neighbourhood characteristics and depression: a twin study.Journal of epidemiology and community health · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The social environment plays a considerable role in determining major psychiatric disorders. Emerging evidence suggests that features of the social environment modify gene expression independently of the primary DNA sequence through epigenetic processes. Accordingly, dysfunction of epigenetic mechanisms offers a plausible mechanism by which an adverse social environment gets "into the mind" and results in poor mental health. The purpose of this review is to provide an overview of the studies suggesting that epigenetic changes introduced by the social environment then manifest as psychological consequences. Our goal is to build a platform to discuss the ways in which future epidemiologic studies may benefit from including epigenetic measures. We focus on schizophrenia, major depressive disorder, post-traumatic stress disorder, anorexia nervosa, and substance dependence as examples that highlight the ways in which social environmental exposures, mediated through epigenetic processes, affect mental health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.