ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2012
Genetic association and gene-gene interaction analyses in African American dialysis patients with nondiabetic nephropathy.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00301249 (The Family Investigation of Nephropathy and Diabetes), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Family Investigation of Nephropathy and Diabetes (FIND) Study
Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci.Journal of the American Society of Nephrology : JASN · 2025Article
- Protein-truncating variant in APOL3 increases chronic kidney disease risk in epistasis with APOL1 risk alleles.JCI insight · 2024Article
- Employment status at transplant influences ethnic disparities in outcomes after deceased donor kidney transplantation.BMC nephrology · 2022Article
- Article
- JC Virus andKidney international reports · 2019Article
- Genetics, Genomics, and Precision Medicine in End-Stage Kidney Disease.Seminars in nephrology · 2018Review
- An Exome-wide Association Study for Type 2 Diabetes-Attributed End-Stage Kidney Disease in African Americans.Kidney international reports · 2018Article
- APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death.Journal of the American Society of Nephrology : JASN · 2017Article
- Race, APOL1 Risk, and eGFR Decline in the General Population.Journal of the American Society of Nephrology : JASN · 2016Article
- Interplay between Superoxide Dismutase, Glutathione Peroxidase, and Peroxisome Proliferator Activated Receptor Gamma Polymorphisms on the Risk of End-Stage Renal Disease among Han Chinese Patients.Oxidative medicine and cellular longevity · 2016Article
- Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1.American journal of physiology. Cell physiology · 2015Article
- The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease.Human molecular genetics · 2014Article
- Gene-gene and gene-environment interactions in apolipoprotein L1 gene-associated nephropathy.Clinical journal of the American Society of Nephrology : CJASN · 2014Review
- APOL1 kidney risk alleles: population genetics and disease associations.Advances in chronic kidney disease · 2014Review
- The impact of APOL1, CAV1, and ABCB1 gene variants on outcomes in kidney transplantation: donor and recipient effects.Pediatric nephrology (Berlin, Germany) · 2014Review
- Complement factor H gene associations with end-stage kidney disease in African Americans.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014Article
- Gene-gene interactions in APOL1-associated nephropathy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014Article
- JC viruria and kidney disease in APOL1 risk genotype individuals: is this a clue to a gene × environment interaction?Kidney international · 2013Article
- JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy.Kidney international · 2013Article
Corrections and comments
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Authors and funding
26 authors at 13 institutions in 2 countries.
Funding
Abstract
backgroundAfrican Americans have increased susceptibility to nondiabetic nephropathy relative to European Americans. STUDY
designFollow-up of a pooled genome-wide association study (GWAS) in African American dialysis patients with nondiabetic nephropathy; novel gene-gene interaction analyses. SETTING &
participantsWake Forest sample: 962 African American nondiabetic nephropathy cases, 931 non-nephropathy controls. Replication sample: 668 Family Investigation of Nephropathy and Diabetes (FIND) African American nondiabetic nephropathy cases, 804 non-nephropathy controls. PREDICTORS: Individual genotyping of top 1,420 pooled GWAS-associated single-nucleotide polymorphisms (SNPs) and 54 SNPs in 6 nephropathy susceptibility genes. OUTCOMES: APOL1 genetic association and additional candidate susceptibility loci interacting with or independently from APOL1.
resultsThe strongest GWAS associations included 2 noncoding APOL1 SNPs, rs2239785 (OR, 0.33; dominant; P = 5.9 × 10(-24)) and rs136148 (OR, 0.54; additive; P = 1.1 × 10(-7)) with replication in FIND (P = 5.0 × 10(-21) and 1.9 × 10(-05), respectively). rs2239785 remained associated significantly after controlling for the APOL1 G1 and G2 coding variants. Additional top hits included a CFH SNP (OR from meta-analysis in the 3,367 African American cases and controls, 0.81; additive; P = 6.8 × 10(-4)). The 1,420 SNPs were tested for interaction with APOL1 G1 and G2 variants. Several interactive SNPs were detected; the most significant was rs16854341 in the podocin gene (NPHS2; P = 0.0001). LIMITATIONS: Nonpooled GWASs have not been performed in African American patients with nondiabetic nephropathy.
conclusionsThis follow-up of a pooled GWAS provides additional and independent evidence that APOL1 variants contribute to nondiabetic nephropathy in African Americans and identified additional associated and interactive nondiabetic nephropathy susceptibility genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.